1e5d

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[[Image:1e5d.jpg|left|200px]]
[[Image:1e5d.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1e5d |SIZE=350|CAPTION= <scene name='initialview01'>1e5d</scene>, resolution 2.50&Aring;
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The line below this paragraph, containing "STRUCTURE_1e5d", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=FEA:Diiron+Redox+Catalytic+Site+For+Direct+Dioxygen+To+Water+...'>FEA</scene>, <scene name='pdbsite=FEB:Diiron+Redox+Catalytic+Site+For+Direct+Dioxygen+To+Water+...'>FEB</scene>, <scene name='pdbsite=FMA:Fmn+Binding+Site+For+Chain+A'>FMA</scene> and <scene name='pdbsite=FMB:Fmn+Binding+Site+For+Chain+B'>FMB</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=FEO:MU-OXO-DIIRON'>FEO</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=OXY:OXYGEN+MOLECULE'>OXY</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1e5d| PDB=1e5d | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e5d OCA], [http://www.ebi.ac.uk/pdbsum/1e5d PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1e5d RCSB]</span>
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}}
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'''RUBREDOXIN OXYGEN:OXIDOREDUCTASE (ROO) FROM ANAEROBE DESULFOVIBRIO GIGAS'''
'''RUBREDOXIN OXYGEN:OXIDOREDUCTASE (ROO) FROM ANAEROBE DESULFOVIBRIO GIGAS'''
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[[Category: Teixeira, M.]]
[[Category: Teixeira, M.]]
[[Category: Xavier, A V.]]
[[Category: Xavier, A V.]]
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[[Category: diiron-centre]]
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[[Category: Diiron-centre]]
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[[Category: flavoprotein]]
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[[Category: Flavoprotein]]
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[[Category: lactamase-fold]]
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[[Category: Lactamase-fold]]
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[[Category: oxidoreductase]]
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[[Category: Oxidoreductase]]
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[[Category: oxygenreductase]]
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[[Category: Oxygenreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:41:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:55:26 2008''
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Revision as of 11:41, 2 May 2008

Image:1e5d.jpg

Template:STRUCTURE 1e5d

RUBREDOXIN OXYGEN:OXIDOREDUCTASE (ROO) FROM ANAEROBE DESULFOVIBRIO GIGAS


Overview

Desulfovibrio gigas is a strict anaerobe that contains a well-characterized metabolic pathway that enables it to survive transient contacts with oxygen. The terminal enzyme in this pathway, rubredoxin:oxygen oxidoreductase (ROO) reduces oxygen to water in a direct and safe way. The 2.5 A resolution crystal structure of ROO shows that each monomer of this homodimeric enzyme consists of a novel combination of two domains, a flavodoxin-like domain and a Zn-beta-lactamase-like domain that contains a di-iron center for dioxygen reduction. This is the first structure of a member of a superfamily of enzymes widespread in strict and facultative anaerobes, indicating its broad physiological significance.

About this Structure

1E5D is a Single protein structure of sequence from Desulfovibrio gigas. Full crystallographic information is available from OCA.

Reference

Structure of a dioxygen reduction enzyme from Desulfovibrio gigas., Frazao C, Silva G, Gomes CM, Matias P, Coelho R, Sieker L, Macedo S, Liu MY, Oliveira S, Teixeira M, Xavier AV, Rodrigues-Pousada C, Carrondo MA, Le Gall J, Nat Struct Biol. 2000 Nov;7(11):1041-5. PMID:11062560 Page seeded by OCA on Fri May 2 14:41:00 2008

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OCA

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