6ye9

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==Small-molecule inhibitor of 14-3-3 protein-protein interactions==
==Small-molecule inhibitor of 14-3-3 protein-protein interactions==
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<StructureSection load='6ye9' size='340' side='right'caption='[[6ye9]]' scene=''>
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<StructureSection load='6ye9' size='340' side='right'caption='[[6ye9]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YE9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YE9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6ye9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YE9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YE9 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ye9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ye9 OCA], [https://pdbe.org/6ye9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ye9 RCSB], [https://www.ebi.ac.uk/pdbsum/6ye9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ye9 ProSAT]</span></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OO8:[2-[2-oxidanylidene-2-[(phenylmethyl)amino]ethoxy]phenyl]phosphonic+acid'>OO8</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SFN, HME1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ye9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ye9 OCA], [https://pdbe.org/6ye9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ye9 RCSB], [https://www.ebi.ac.uk/pdbsum/6ye9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ye9 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN]] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression.
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Ottmann C]]
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[[Category: Ottmann, C]]
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[[Category: Visser EJ]]
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[[Category: Visser, E J]]
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[[Category: 14-3-3]]
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[[Category: Inhibitor]]
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[[Category: Protein-protein interaction]]
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[[Category: Small molecule]]
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[[Category: Structural protein]]

Revision as of 06:54, 14 April 2021

Small-molecule inhibitor of 14-3-3 protein-protein interactions

PDB ID 6ye9

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