2kiu
From Proteopedia
(Difference between revisions)
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==Solution structure and backbone dynamics of the DNA-binding domain of FOXP1: Insight into its domain swapping== | ==Solution structure and backbone dynamics of the DNA-binding domain of FOXP1: Insight into its domain swapping== | ||
| - | <StructureSection load='2kiu' size='340' side='right' caption='[[2kiu]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | + | <StructureSection load='2kiu' size='340' side='right'caption='[[2kiu]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2kiu]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2kiu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KIU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KIU FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">3p14.1, FOXP1, HSPC215 ([ | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">3p14.1, FOXP1, HSPC215 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kiu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kiu OCA], [https://pdbe.org/2kiu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kiu RCSB], [https://www.ebi.ac.uk/pdbsum/2kiu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kiu ProSAT]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/FOXP1_HUMAN FOXP1_HUMAN]] MALT lymphoma;Precursor B-cell acute lymphoblastic leukemia;Intellectual disability-severe speech delay-mild dysmorphism syndrome. A chromosomal aberration involving FOXP1 is found in acute lymphoblastic leukemia. Translocation t(9;3)(p13;p14.1) with PAX5. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:20950788</ref> |
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/FOXP1_HUMAN FOXP1_HUMAN]] Transcriptional repressor. It plays an important role in the specification and differentiation of lung epithelium. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Essential transcriptional regulator of B-cell development (By similarity).<ref>PMID:20950788</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
| - | *[[ | + | *[[FOX 3D structures|FOX 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Chu, Y]] | [[Category: Chu, Y]] | ||
[[Category: Chuang, W]] | [[Category: Chuang, W]] | ||
Revision as of 07:26, 14 April 2021
Solution structure and backbone dynamics of the DNA-binding domain of FOXP1: Insight into its domain swapping
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