2kvd
From Proteopedia
(Difference between revisions)
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==Mesencephalic astrocyte-derived neurotrophic factor (MANF)== | ==Mesencephalic astrocyte-derived neurotrophic factor (MANF)== | ||
| - | <StructureSection load='2kvd' size='340' side='right' caption='[[2kvd]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''> | + | <StructureSection load='2kvd' size='340' side='right'caption='[[2kvd]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2kvd]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2kvd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KVD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KVD FirstGlance]. <br> |
| - | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2kve|2kve]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2kve|2kve]]</div></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">mesencephalic astrocyte-derived neurotrophic factor ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">mesencephalic astrocyte-derived neurotrophic factor ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kvd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kvd OCA], [https://pdbe.org/2kvd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kvd RCSB], [https://www.ebi.ac.uk/pdbsum/2kvd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kvd ProSAT]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/MANF_HUMAN MANF_HUMAN]] Familial pancreatic carcinoma. |
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/MANF_HUMAN MANF_HUMAN]] Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons (By similarity). Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death.<ref>PMID:12794311</ref> <ref>PMID:18561914</ref> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Hellman, M H]] | [[Category: Hellman, M H]] | ||
[[Category: Peranen, J]] | [[Category: Peranen, J]] | ||
Revision as of 07:32, 14 April 2021
Mesencephalic astrocyte-derived neurotrophic factor (MANF)
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