2l35

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==Structure of the DAP12-NKG2C transmembrane heterotrimer==
==Structure of the DAP12-NKG2C transmembrane heterotrimer==
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<StructureSection load='2l35' size='340' side='right' caption='[[2l35]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
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<StructureSection load='2l35' size='340' side='right'caption='[[2l35]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2l35]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L35 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L35 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2l35]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L35 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L35 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2l34|2l34]], [[2hac|2hac]], [[2k4f|2k4f]]</td></tr>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2l34|2l34]], [[2hac|2hac]], [[2k4f|2k4f]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TYROBP, DAP12, KARAP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TYROBP, DAP12, KARAP ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l35 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l35 OCA], [http://pdbe.org/2l35 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2l35 RCSB], [http://www.ebi.ac.uk/pdbsum/2l35 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2l35 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l35 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l35 OCA], [https://pdbe.org/2l35 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l35 RCSB], [https://www.ebi.ac.uk/pdbsum/2l35 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l35 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/TYOBP_HUMAN TYOBP_HUMAN]] Nasu-Hakola disease. The disease is caused by mutations affecting the gene represented in this entry.
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[[https://www.uniprot.org/uniprot/TYOBP_HUMAN TYOBP_HUMAN]] Nasu-Hakola disease. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TYOBP_HUMAN TYOBP_HUMAN]] Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin.
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[[https://www.uniprot.org/uniprot/TYOBP_HUMAN TYOBP_HUMAN]] Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Call, M E]]
[[Category: Call, M E]]
[[Category: Chou, J J]]
[[Category: Chou, J J]]

Revision as of 07:35, 14 April 2021

Structure of the DAP12-NKG2C transmembrane heterotrimer

PDB ID 2l35

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