2l7f
From Proteopedia
(Difference between revisions)
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==Solution Structure of the Pitx2 Homeodomain== | ==Solution Structure of the Pitx2 Homeodomain== | ||
| - | <StructureSection load='2l7f' size='340' side='right' caption='[[2l7f]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | + | <StructureSection load='2l7f' size='340' side='right'caption='[[2l7f]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2l7f]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2l7f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L7F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L7F FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PITX2, ARP1, RGS, RIEG, RIEG1 ([ | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PITX2, ARP1, RGS, RIEG, RIEG1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l7f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l7f OCA], [https://pdbe.org/2l7f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l7f RCSB], [https://www.ebi.ac.uk/pdbsum/2l7f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l7f ProSAT]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/PITX2_HUMAN PITX2_HUMAN]] Peters anomaly;Axenfeld anomaly;Rieger anomaly;Ring dermoid of cornea;Axenfeld-Rieger syndrome. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. |
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/PITX2_HUMAN PITX2_HUMAN]] Controls cell proliferation in a tissue-specific manner and is involved in morphogenesis. During embryonic development, exerts a role in the expansion of muscle progenitors. May play a role in the proper localization of asymmetric organs such as the heart and stomach. Isoform PTX2C is involved in left-right asymmetry the developing embryo (By similarity). |
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Baird-Titus, J M]] | [[Category: Baird-Titus, J M]] | ||
[[Category: Doerdelmann, T]] | [[Category: Doerdelmann, T]] | ||
Revision as of 07:37, 14 April 2021
Solution Structure of the Pitx2 Homeodomain
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