2l7m
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Solution Structure of the Pitx2 Homeodomain R24H mutant== | ==Solution Structure of the Pitx2 Homeodomain R24H mutant== | ||
| - | <StructureSection load='2l7m' size='340' side='right' caption='[[2l7m]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | + | <StructureSection load='2l7m' size='340' side='right'caption='[[2l7m]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2l7m]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2l7m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L7M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L7M FirstGlance]. <br> |
| - | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2l7f|2l7f]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2l7f|2l7f]]</div></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PITX2, ARP1, RGS, RIEG, RIEG1 ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PITX2, ARP1, RGS, RIEG, RIEG1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l7m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l7m OCA], [https://pdbe.org/2l7m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l7m RCSB], [https://www.ebi.ac.uk/pdbsum/2l7m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l7m ProSAT]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/PITX2_HUMAN PITX2_HUMAN]] Peters anomaly;Axenfeld anomaly;Rieger anomaly;Ring dermoid of cornea;Axenfeld-Rieger syndrome. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. |
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/PITX2_HUMAN PITX2_HUMAN]] Controls cell proliferation in a tissue-specific manner and is involved in morphogenesis. During embryonic development, exerts a role in the expansion of muscle progenitors. May play a role in the proper localization of asymmetric organs such as the heart and stomach. Isoform PTX2C is involved in left-right asymmetry the developing embryo (By similarity). |
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Baird-Titus, J M]] | [[Category: Baird-Titus, J M]] | ||
[[Category: Doerdelmann, T]] | [[Category: Doerdelmann, T]] | ||
Revision as of 07:37, 14 April 2021
Solution Structure of the Pitx2 Homeodomain R24H mutant
| |||||||||||
