2l7w
From Proteopedia
(Difference between revisions)
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==Solution structure of the human Raf-1 kinase inhibitor protein== | ==Solution structure of the human Raf-1 kinase inhibitor protein== | ||
| - | <StructureSection load='2l7w' size='340' side='right' caption='[[2l7w]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | + | <StructureSection load='2l7w' size='340' side='right'caption='[[2l7w]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2l7w]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2l7w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L7W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L7W FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RKIP ([ | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RKIP ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l7w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l7w OCA], [https://pdbe.org/2l7w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l7w RCSB], [https://www.ebi.ac.uk/pdbsum/2l7w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l7w ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/PEBP1_HUMAN PEBP1_HUMAN]] Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation.<ref>PMID:18294816</ref> HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity).<ref>PMID:18294816</ref> |
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Yi, C Y]] | [[Category: Yi, C Y]] | ||
[[Category: Raf-1 kinase inhibitor protein]] | [[Category: Raf-1 kinase inhibitor protein]] | ||
[[Category: Signaling protein inhibitor]] | [[Category: Signaling protein inhibitor]] | ||
Revision as of 07:38, 14 April 2021
Solution structure of the human Raf-1 kinase inhibitor protein
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