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Function of your protein

serves as a metabolic housekeeping enzyme due to its ability to detoxify aldehydes, which are highly reactive compounds generated through cellular. It can also scavenge aldehyde from lipid peroxidation and convert them to a less chemically reactive carboxylic acid. Aldc additionally plays an important role in ethanol metabolism via oxidation of acetaldehyde into acetate, metabolism of polyamine, and plant cell wall ester biogenesis,as you can be by the .

Biological relevance and broader implications

Important amino acids

 Asn 159, Glu 257, Gly 288, Cys 291

19 NAD+ Residues (binding site)

 Ile 155, Asn 159, Lys 182, Gly 219, Ile 233, Ser 236, Ala 239, leu 242, Glu 257, leu 258, Gly 259, Cys 291, Glu 391, Phe 393

Octanol Lingand (binding site)

 Trp 160 Tyr 163, Trp 450, Phe 456, Tyr 458, met 114, leu 118

Structural highlights

Aldc's secondary structure has two domains, hydrophobic and hydrophilic regions. The N-terminus of Aldc contains a central beta sheet surrounded by alpha helices which forms the NAD9H) binding site. Additionally, around the C-terminus there is a mixture of alpha and beta domains including the cysteine residue and this is where the aldehyde binding site forms.

Other important features

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