We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.
User:Maggie Stopa/Sandbox 1
From Proteopedia
(Difference between revisions)
| Line 16: | Line 16: | ||
==Structure== | ==Structure== | ||
| - | + | ||
==Mechanism== | ==Mechanism== | ||
Lipoprotein Lipase functions to catalyze the hydrolysis of one ester bond of triglycerides. It does this by utilizing a simple serine hydrolase mechanism, in which it uses a <scene name='87/877516/Catalytic_triad_master/1'>Catalytic Triad</scene> composed of Asp183, His268, and Ser159 to catalyze the hydrolysis. His268 serves as a base catalyst by deprotonating Ser159, which can then serve as the nucleophile. The transition state of the catalysis is stabilized by the <scene name='87/877516/Oxyanion_hole_master/1'>Oxyanion Hole</scene> composed of Trp82 and Leu160. The hydrolysis results in the formation of one free fatty acid and a glycerol with two fatty acid tails. | Lipoprotein Lipase functions to catalyze the hydrolysis of one ester bond of triglycerides. It does this by utilizing a simple serine hydrolase mechanism, in which it uses a <scene name='87/877516/Catalytic_triad_master/1'>Catalytic Triad</scene> composed of Asp183, His268, and Ser159 to catalyze the hydrolysis. His268 serves as a base catalyst by deprotonating Ser159, which can then serve as the nucleophile. The transition state of the catalysis is stabilized by the <scene name='87/877516/Oxyanion_hole_master/1'>Oxyanion Hole</scene> composed of Trp82 and Leu160. The hydrolysis results in the formation of one free fatty acid and a glycerol with two fatty acid tails. | ||
| Line 29: | Line 29: | ||
[[Image:LLP11.jpg|300 px|left|thumb|LPL Image]] | [[Image:LLP11.jpg|300 px|left|thumb|LPL Image]] | ||
| - | + | <scene name='87/877513/Hydrophobic_interface/1'>hydrophobic interface</scene> | |
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 19:10, 19 April 2021
Lipoprotein Lipase LPL
| |||||||||||
