1ad5

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(New page: 200px<br /> <applet load="1ad5" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ad5, resolution 2.6&Aring;" /> '''SRC FAMILY KINASE HC...)
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Revision as of 13:51, 12 November 2007

Image:1ad5.gif

1ad5, resolution 2.6Å

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SRC FAMILY KINASE HCK-AMP-PNP COMPLEX

Overview

The crystal structure of the haematopoietic cell kinase Hck has been, determined at 2.6/2.9 A resolution. Inhibition of enzymatic activity is a, consequence of intramolecular interactions of the enzyme's Src-homology, domains SH2 and SH3, with concomitant displacement of elements of the, catalytic domain. The conformation of the active site has similarities, with that of inactive cyclin-dependent protein kinases.

About this Structure

1AD5 is a Single protein structure of sequence from Homo sapiens with CA and ANP as ligands. Active as Transferase, with EC number and 2.7.10.2 2.7.10.1 and 2.7.10.2 Full crystallographic information is available from OCA.

Reference

Crystal structure of the Src family tyrosine kinase Hck., Sicheri F, Moarefi I, Kuriyan J, Nature. 1997 Feb 13;385(6617):602-9. PMID:9024658

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