1ad6
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(New page: 200px<br /> <applet load="1ad6" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ad6, resolution 2.3Å" /> '''DOMAIN A OF HUMAN RE...)
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Revision as of 13:51, 12 November 2007
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DOMAIN A OF HUMAN RETINOBLASTOMA TUMOR SUPPRESSOR
Contents |
Overview
The pocket region of retinoblastoma tumour suppressor (Rb) is essential, for tumour suppressing activity. The Rb pocket is primarily composed of, two domains, A and B. We have determined the X-ray crystal structure of, domain A (residues 378-562) at 2.3 A resolution. Domain A consists of nine, alpha-helices. The overall arrangement of helices in domain A is, remarkably similar to the cyclin-box folds found in the crystal structures, of cyclin A and TFIIB. This structure, along with domain B which is, predicted to be homologous to the cyclin-box, suggests that the Rb pocket, is composed of two cyclin-box fold domains. We present the, structural/functional features of the Rb pocket, and the potential binding, region for cellular or viral proteins within domain A.
Disease
Known diseases associated with this structure: Bladder cancer OMIM:[180200], Osteosarcoma OMIM:[180200], Pinealoma with bilateral retinoblastoma OMIM:[180200], Retinoblastoma OMIM:[180200]
About this Structure
1AD6 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structural similarity between the pocket region of retinoblastoma tumour suppressor and the cyclin-box., Kim HY, Cho Y, Nat Struct Biol. 1997 May;4(5):390-5. PMID:9145110
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