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1e7k

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[[Image:1e7k.gif|left|200px]]
[[Image:1e7k.gif|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1e7k", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
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{{STRUCTURE_1e7k| PDB=1e7k | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e7k OCA], [http://www.ebi.ac.uk/pdbsum/1e7k PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1e7k RCSB]</span>
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'''CRYSTAL STRUCTURE OF THE SPLICEOSOMAL 15.5KD PROTEIN BOUND TO A U4 SNRNA FRAGMENT'''
'''CRYSTAL STRUCTURE OF THE SPLICEOSOMAL 15.5KD PROTEIN BOUND TO A U4 SNRNA FRAGMENT'''
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[[Category: Nottrott, S.]]
[[Category: Nottrott, S.]]
[[Category: Vidovic, I.]]
[[Category: Vidovic, I.]]
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[[Category: rna recognition motif]]
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[[Category: Rna recognition motif]]
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[[Category: splicing]]
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[[Category: Splicing]]
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[[Category: u4 snrna]]
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[[Category: U4 snrna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:45:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:56:50 2008''
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Revision as of 11:45, 2 May 2008

Image:1e7k.gif

Template:STRUCTURE 1e7k

CRYSTAL STRUCTURE OF THE SPLICEOSOMAL 15.5KD PROTEIN BOUND TO A U4 SNRNA FRAGMENT


Overview

We have determined the crystal structure of a spliceosomal RNP complex comprising the 15.5kD protein of the human U4/U6.U5 tri-snRNP and the 5' stem-loop of U4 snRNA. The protein interacts almost exclusively with a purine-rich (5+2) internal loop within the 5' stem-loop, giving an unusual RNA fold characterized by two tandem sheared G-A base pairs, a high degree of purine stacking, and the accommodation of a single RNA base, rotated out of the RNA chain, in a pocket of the protein. Apart from yielding the structure of an important entity in the pre-mRNA splicing apparatus, this work also implies a model for the complex of the 15.5kD protein with box C/D snoRNAs. It additionally suggests a general recognition principle in a novel family of RNA binding proteins.

About this Structure

1E7K is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the spliceosomal 15.5kD protein bound to a U4 snRNA fragment., Vidovic I, Nottrott S, Hartmuth K, Luhrmann R, Ficner R, Mol Cell. 2000 Dec;6(6):1331-42. PMID:11163207 Page seeded by OCA on Fri May 2 14:45:46 2008

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