1e85

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[[Image:1e85.jpg|left|200px]]
[[Image:1e85.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1e85 |SIZE=350|CAPTION= <scene name='initialview01'>1e85</scene>, resolution 1.35&Aring;
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The line below this paragraph, containing "STRUCTURE_1e85", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=HEC:Hec+Binding+Site+For+Chain+A'>HEC</scene> and <scene name='pdbsite=NMO:Nmo+Binding+Site+For+Chain+A'>NMO</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=HEC:HEME+C'>HEC</scene>, <scene name='pdbligand=NO:NITROGEN+OXIDE'>NO</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1e85| PDB=1e85 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e85 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e85 OCA], [http://www.ebi.ac.uk/pdbsum/1e85 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1e85 RCSB]</span>
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}}
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'''CYTOCHROME C' FROM ALCALIGENES XYLOSOXIDANS-REDUCED STRUCTURE WITH NO BOUND TO PROXIMAL SIDE OF HEME'''
'''CYTOCHROME C' FROM ALCALIGENES XYLOSOXIDANS-REDUCED STRUCTURE WITH NO BOUND TO PROXIMAL SIDE OF HEME'''
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[[Category: Stevenson, C E.M.]]
[[Category: Stevenson, C E.M.]]
[[Category: 4-helix bundle]]
[[Category: 4-helix bundle]]
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[[Category: cytochrome]]
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[[Category: Cytochrome]]
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[[Category: heme]]
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[[Category: Heme]]
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[[Category: nitric oxide]]
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[[Category: Nitric oxide]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:46:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:57:12 2008''
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Revision as of 11:46, 2 May 2008

Image:1e85.jpg

Template:STRUCTURE 1e85

CYTOCHROME C' FROM ALCALIGENES XYLOSOXIDANS-REDUCED STRUCTURE WITH NO BOUND TO PROXIMAL SIDE OF HEME


Overview

Microbial cytochromes c' contain a 5-coordinate His-ligated heme that forms stable adducts with nitric oxide (NO) and carbon monoxide (CO), but not with dioxygen. We report the 1.95 and 1.35 A resolution crystal structures of the CO- and NO-bound forms of the reduced protein from Alcaligenes xylosoxidans. NO disrupts the His-Fe bond and binds in a novel mode to the proximal face of the heme, giving a 5-coordinate species. In contrast, CO binds 6-coordinate on the distal side. A second CO molecule, not bound to the heme, is located in the proximal pocket. Since the unusual spectroscopic properties of cytochromes c' are shared by soluble guanylate cyclase (sGC), our findings have potential implications for the activation of sGC induced by the binding of NO or CO to the heme domain.

About this Structure

1E85 is a Single protein structure of sequence from Achromobacter xylosoxidans. Full crystallographic information is available from OCA.

Reference

Unprecedented proximal binding of nitric oxide to heme: implications for guanylate cyclase., Lawson DM, Stevenson CE, Andrew CR, Eady RR, EMBO J. 2000 Nov 1;19(21):5661-71. PMID:11060017 Page seeded by OCA on Fri May 2 14:46:58 2008

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