1e8b
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:1e8b.jpg|left|200px]] | [[Image:1e8b.jpg|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_1e8b", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
| - | | | + | or leave the SCENE parameter empty for the default display. |
| - | | | + | --> |
| - | + | {{STRUCTURE_1e8b| PDB=1e8b | SCENE= }} | |
| - | + | ||
| - | + | ||
| - | }} | + | |
'''SOLUTION STRUCTURE OF 6F11F22F2, A COMPACT THREE-MODULE FRAGMENT OF THE GELATIN-BINDING DOMAIN OF HUMAN FIBRONECTIN''' | '''SOLUTION STRUCTURE OF 6F11F22F2, A COMPACT THREE-MODULE FRAGMENT OF THE GELATIN-BINDING DOMAIN OF HUMAN FIBRONECTIN''' | ||
| Line 30: | Line 27: | ||
[[Category: Smith, S P.]] | [[Category: Smith, S P.]] | ||
[[Category: Staunton, D.]] | [[Category: Staunton, D.]] | ||
| - | [[Category: | + | [[Category: Extracellular matrix glycoprotein]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:47:19 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 11:47, 2 May 2008
SOLUTION STRUCTURE OF 6F11F22F2, A COMPACT THREE-MODULE FRAGMENT OF THE GELATIN-BINDING DOMAIN OF HUMAN FIBRONECTIN
Overview
The solution structure of the (6)F1(1)F2(2)F2 fragment from the gelatin-binding region of fibronectin has been determined (Protein Data Bank entry codes 1e88 and 1e8b). The structure reveals an extensive hydrophobic interface between the non-contiguous (6)F1 and (2)F2 modules. The buried surface area between (6)F1 and (2)F2 ( approximately 870 A(2)) is the largest intermodule interface seen in fibronectin to date. The dissection of (6)F1(1)F2(2)F2 into the (6)F1(1)F2 pair and (2)F2 results in near-complete loss of gelatin-binding activity. The hairpin topology of (6)F1(1)F2(2)F2 may facilitate intramolecular contact between the matrix assembly regions flanking the gelatin-binding domain. This is the first high-resolution study to reveal a compact, globular arrangement of modules in fibronectin. This arrangement is not consistent with the view that fibronectin is simply a linear 'string of beads'.
About this Structure
1E8B is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The hairpin structure of the (6)F1(1)F2(2)F2 fragment from human fibronectin enhances gelatin binding., Pickford AR, Smith SP, Staunton D, Boyd J, Campbell ID, EMBO J. 2001 Apr 2;20(7):1519-29. PMID:11285216 Page seeded by OCA on Fri May 2 14:47:19 2008
