This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Sandbox GGC16
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==PU.1== | ==PU.1== | ||
<StructureSection load='1PUE' size='340' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='1PUE' size='340' side='right' caption='Caption for this structure' scene=''> | ||
| - | PU.1 is a hematopoietic transcription factor. It specifically regulates transcription of | + | PU.1 is a hematopoietic transcription factor. It specifically regulates transcription of genes specific to myeloid and lymphoid cells, ultimately leading to cellular differentiation. |
| - | == Name == | + | == Name and Location == |
The name PU.1 comes from the protein's binding interactions with a purine-rich DNA sequence. | The name PU.1 comes from the protein's binding interactions with a purine-rich DNA sequence. | ||
<scene name='87/874948/Earpurinerich/2'>Bases at Interface</scene> | <scene name='87/874948/Earpurinerich/2'>Bases at Interface</scene> | ||
| + | The protein resides in the nucleus. | ||
| - | == Function == | ||
===Binding Domain=== | ===Binding Domain=== | ||
| - | <scene name='87/874948/ | + | <scene name='87/874948/Earbindingresiduesbest/1'>Residues at Binding Domain</scene> |
| + | Ets binding domain is conserved across the Ets family of proteins. | ||
| + | Binding domain is positively charged. Residues most closely interacting with DNA include Arginine and Lysine. | ||
== Disease == | == Disease == | ||
| + | PU.1 has been identified as an oncogene. Mutations have been identified in patients with leukemias and lymphomas. Interestingly, the mutations are not always identified within the binding site. | ||
| + | |||
| + | == PEST domain == | ||
| - | == Relevance == | ||
== Structural highlights == | == Structural highlights == | ||
Revision as of 15:44, 24 April 2021
PU.1
| |||||||||||
