Sandbox GGC6

Neurotrophin-4 (NFT-4) is a neuronal growth factor that influences nerve cell proliferation through selective and non-covalent interactions with the nerve growth factor receptor.

Function

NFT-4 functions as a growth factor in many biological pathways and processes to induce neuronal proliferation.

Biological Processes

• Positive regulation of neurotrophin TRK receptor signaling pathway:

NFT-4 functions as a ligand when binding to neurotrophin receptor tyrosine kinase NTRK2. Auto-phosphorylated NTRK2 dimers that are formed on tyrosine residues in receptor tail as a result of NFT-4 binding.

Relevance

Structural highlights

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