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1amb
From Proteopedia
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(New page: 200px<br /> <applet load="1amb" size="450" color="white" frame="true" align="right" spinBox="true" caption="1amb" /> '''SOLUTION STRUCTURE OF RESIDUES 1-28 OF THE ...)
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Revision as of 13:53, 12 November 2007
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SOLUTION STRUCTURE OF RESIDUES 1-28 OF THE AMYLOID BETA-PEPTIDE
Contents |
Overview
The three-dimensional solution structure of residues 1-28 of the amyloid, beta-peptide was determined using nuclear magnetic resonance spectroscopy, distance geometry, and molecular dynamic techniques. The nuclear magnetic, resonance data used to derive the structure consisted of nuclear, Overhauser enhancements, vicinal coupling constants, and temperature, coefficients of the amide-NH chemical shifts. The beta-peptide is the, major proteinaceous component of amyloid deposits in Alzheimer's disease., In membrane-like media, the peptide folds to form a predominately, alpha-helical structure with a bend centered at residue 12. The side, chains of histidine-13 and lysine-16 are close, residing on the same face, of the helix. Their proximity may constitute a binding motif with the, heparan sulfate proteoglycans. The molecular details of the structure, shown here could facilitate the design of rational treatments to curtail, the binding of heparan sulfate proteoglycans or to prevent an, alpha-helix-->beta-sheet conversion that may occur during the early stages, of amyloid formation in Alzheimer's disease.
Disease
Known diseases associated with this structure: Alzheimer disease-1, APP-related OMIM:[104760], Amyloidosis, cerebroarterial, Dutch type OMIM:[104760], Amyloidosis, cerebroarterial, Iowa type OMIM:[104760], Blood group, P system OMIM:[607922]
About this Structure
1AMB is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Solution structure of residues 1-28 of the amyloid beta-peptide., Talafous J, Marcinowski KJ, Klopman G, Zagorski MG, Biochemistry. 1994 Jun 28;33(25):7788-96. PMID:7516706
Page seeded by OCA on Mon Nov 12 15:59:53 2007
