B-cell lymphoma proteins 3D structures

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*Bcl-xL (Bcl-2-like protein 1)
*Bcl-xL (Bcl-2-like protein 1)
-
**[[1maz]], [[1r2d]], [[2b48]], [[4ppi]] – hBcl-xL – human<br />
+
**[[1maz]], [[1r2d]], [[2b48]], [[4ppi]], [[7ca4]] – hBcl-xL – human<br />
**[[1r2e]], [[1r2g]], [[1r2h]], [[1r2i]], [[3cva]] - hBcl-xL (mutant)<br />
**[[1r2e]], [[1r2g]], [[1r2h]], [[1r2i]], [[3cva]] - hBcl-xL (mutant)<br />
**[[2lpc]], [[2m03]], [[2me8]], [[2me9]], [[1lxl]] - hBcl-xL – NMR<br />
**[[2lpc]], [[2m03]], [[2me8]], [[2me9]], [[1lxl]] - hBcl-xL – NMR<br />
**[[6bf2]] - hBcl-xL (mutant) – NMR<br />
**[[6bf2]] - hBcl-xL (mutant) – NMR<br />
 +
**[[6x7i]] - hBcl-xL C terminal - NMR<br />
**[[3fdm]] - hBcl-xL + α/β peptide foldamer<br />
**[[3fdm]] - hBcl-xL + α/β peptide foldamer<br />
**[[2mej]] - hBcl-xL + p53 - NMR<br />
**[[2mej]] - hBcl-xL + p53 - NMR<br />
 +
**[[6lhd]] - hBcl-xL/p53 <br />
 +
**[[1ysg]], [[3sp7]], [[3spf]], [[3wiz]], [[4tuh]], [[3zln]], [[3zk6]], [[3zlo]], [[3zlr]], [[4c52]], [[4c5d]], [[2yxj]], [[4qnq]], [[4qvx]], [[6rnu]], [[6vwc]], [[7jgv]], [[7jgw]] - hBcl-xL + inhibitor<br />
**[[3inq]] - hBcl-xL (mutant) + inhibitor<br />
**[[3inq]] - hBcl-xL (mutant) + inhibitor<br />
-
**[[1ysg]], [[3sp7]], [[3spf]], [[3wiz]], [[4tuh]], [[3zln]], [[3zk6]], [[3zlo]], [[3zlr]], [[4c52]], [[4c5d]], [[2yxj]], [[4qnq]], [[4qvx]] - hBcl-xL + inhibitor<br />
 
**[[2w3l]] – hBcl-xL + quinoline derivative<br />
**[[2w3l]] – hBcl-xL + quinoline derivative<br />
**[[2o1y]], [[2o2m]], [[2o2n]], [[1ysi]], [[1ysn]], [[2o21]], [[2o22]], [[2o2f]] - hBcl-xL + sulfonamide derivative – NMR<br />
**[[2o1y]], [[2o2m]], [[2o2n]], [[1ysi]], [[1ysn]], [[2o21]], [[2o22]], [[2o2f]] - hBcl-xL + sulfonamide derivative – NMR<br />
**[[3qkd]], [[4ehr]] - hBcl-xL + sulfonamide derivative<br />
**[[3qkd]], [[4ehr]] - hBcl-xL + sulfonamide derivative<br />
**[[2pon]] - hBcl-xL + Beclin-1 residues 1-23 - NMR<br />
**[[2pon]] - hBcl-xL + Beclin-1 residues 1-23 - NMR<br />
 +
**[[6zhc]] - hBcl-xL + elongin B + elongin C + VHL<br />
 +
**[[6ijq]] - hBcl-xL + p73 peptide - NMR<br />
 +
**[[6yli]] - hBcl-xL + TRBak peptide <br />
 +
**[[6hjl]], [[6st2]], [[6stj]] – hBcl-2-L-1 + affirmer<br />
**[[3ihc]], [[3iih]], [[1pq0]] – mBcl-xL residues 1-196 – mouse<br />
**[[3ihc]], [[3iih]], [[1pq0]] – mBcl-xL residues 1-196 – mouse<br />
**[[3ihd]], [[3ihe]], [[3ihf]], [[3iig]], [[3ilb]], [[3ilc]] - mBcl-xL residues 1-196 (mutant) <br />
**[[3ihd]], [[3ihe]], [[3ihf]], [[3iig]], [[3ilb]], [[3ilc]] - mBcl-xL residues 1-196 (mutant) <br />
Line 23: Line 29:
**[[1pq1]], [[5c3g]] - mBcl-xL residues 1-196 + BIM peptide<br />
**[[1pq1]], [[5c3g]] - mBcl-xL residues 1-196 + BIM peptide<br />
**[[1af3]] - rBcl-xL soluble domain<br />
**[[1af3]] - rBcl-xL soluble domain<br />
 +
**[[6wh0]] - Bcl-xL + BAX peptide - hydra<br />
**[[1bxl]] - Bcl-xL + Bak peptide – Escherichia coli – NMR<br />
**[[1bxl]] - Bcl-xL + Bak peptide – Escherichia coli – NMR<br />
**[[5twa]] - Bcl-xL + Bak peptide – sponge<br />
**[[5twa]] - Bcl-xL + Bak peptide – sponge<br />
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**[[5b1z]] - hBcl-xL + BHX BH3 domain<br />
**[[5b1z]] - hBcl-xL + BHX BH3 domain<br />
**[[4z9v]] - hBcl-xL + TCTP BH3 domain<br />
**[[4z9v]] - hBcl-xL + TCTP BH3 domain<br />
-
**[[6dcn]] - hBcl-xL + Beclin-1 BH3 domain<br />
+
**[[6dcn]], [[6dco]] - hBcl-xL + Beclin-1 BH3 domain<br />
**[[2p1l]] - hBcl-xL (mutant) + Beclin-1 BH3 domain<br />
**[[2p1l]] - hBcl-xL (mutant) + Beclin-1 BH3 domain<br />
**[[2yq6]], [[4qvf]], [[4yk9]], [[3fdl]], [[5agx]], [[4yj4]], [[3io8]], [[2yq7]], [[5vx3]], [[5agw]] - hBcl-xL + BIM BH3 domain<br />
**[[2yq6]], [[4qvf]], [[4yk9]], [[3fdl]], [[5agx]], [[4yj4]], [[3io8]], [[2yq7]], [[5vx3]], [[5agw]] - hBcl-xL + BIM BH3 domain<br />
-
**[[2yj1]], [[4bpk]], [[4hnj]] - hBcl-xL + α/β-Puma BH3 domain<br />
+
**[[2yj1]], [[4bpk]], [[4hnj]] - hBcl-xL + alpha-beta-puma BH3 domain<br />
-
**[[4a1u]], [[4a1w]] - hBcl-xL + α/β-foldamer BH3 domain<br />
+
**[[4a1u]], [[4a1w]] - hBcl-xL + alpha-beta-foldamer BH3 domain<br />
**[[3r85]] - hBcl-xL + heme-binding protein BH3 peptide<br />
**[[3r85]] - hBcl-xL + heme-binding protein BH3 peptide<br />
-
**[[2lp8]] – hBcl-xL + Bcl-2 homologous antagonist/killer BH3 peptide - NMR<br />
+
**[[2lp8]] – hBcl-xL + Bcl-2 homologous antagonist/killer BH3 peptide- NMR<br />
**[[2m04]] – hBcl-xL (mutant) + Bcl-2 binding component 3 BH3 peptide - NMR<br />
**[[2m04]] – hBcl-xL (mutant) + Bcl-2 binding component 3 BH3 peptide - NMR<br />
**[[5wos]] - Bcl-xL + hBIM BH3 domain – canarypox virus<br />
**[[5wos]] - Bcl-xL + hBIM BH3 domain – canarypox virus<br />
**[[5tzp]] - fpvBcl-xL + BIK BH3 domain – fowlpox virus<br />
**[[5tzp]] - fpvBcl-xL + BIK BH3 domain – fowlpox virus<br />
**[[5tzq]] - fpvBcl-xL + Bmf BH3 domain <br />
**[[5tzq]] - fpvBcl-xL + Bmf BH3 domain <br />
 +
**[[6yld]] - Bcl-xL + Bak BH3 domain - Trichoplax<br />
-
*Bcl-2
+
*Bcl-2 or apoptosis regulator Bcl-2
**[[1gjh]], [[1g5m]] – hBcl-2<br />
**[[1gjh]], [[1g5m]] – hBcl-2<br />
-
**[[4aq3]], [[4man]], [[5jsn]], [[4ieh]] – hBcl-2 + inhibitor<br />
+
**[[4aq3]], [[4man]], [[5jsn]], [[4ieh]], [[6gl8]], [[6qgg]], [[6qgj]], [[6qgk]], [[7jmt]] – hBcl-2 + inhibitor<br />
-
**[[4lvt]], [[4lxd]] – hBcl-2 (mutant) + inhibitor<br />
+
**[[4lvt]], [[4lxd]], [[6o0k]], [[6o0m]], [[6o0o]], [[6o0p]] – hBcl-2 (mutant) + inhibitor<br />
 +
**[[7lhb]] – hBcl-2 + drug<br />
**[[5fcg]] – hBcl-2 (mutant) + HBX BH3 domain<br />
**[[5fcg]] – hBcl-2 (mutant) + HBX BH3 domain<br />
**[[2xa0]] – hBcl-2 residues 1-207 + apoptosis regulator Bax BH3 domain<br />
**[[2xa0]] – hBcl-2 residues 1-207 + apoptosis regulator Bax BH3 domain<br />
-
**[[2o21]], [[2o22]], [[2o2f]], [[1ysw]] - hBcl-2 + sulfonamide derivative – NMR
+
**[[2o21]], [[2o22]], [[2o2f]], [[1ysw]] - hBcl-2 + sulfonamide derivative – NMR<br />
 +
**[[6v4m]] – Bcl-2 – Trichuris suis<br />
*Bcl-2-related protein A1 (Bfl-1)
*Bcl-2-related protein A1 (Bfl-1)
 +
**[[6vo4]] - hBcl-2A1<br />
**[[5whi]] - hBcl-2A1 (mutant) <br />
**[[5whi]] - hBcl-2A1 (mutant) <br />
-
**[[2vm6]] – hBcl-2A1 + hBIM BH3 peptide<br />
+
**[[2vm6]], [[3mqp]], [[4zeq]], [[5uuk]], [[5uul]], [[5uup]], [[6e3i]], [[6e3j]], [[6rjp]] - hBcl-2A1 + peptide <br />
**[[2vof]] - mBcl-2A1 + Bcl-2 binding component 3 BH3 peptide <br />
**[[2vof]] - mBcl-2A1 + Bcl-2 binding component 3 BH3 peptide <br />
**[[2vog]] - mBcl-2A1 + Bmf BH3 peptide <br />
**[[2vog]] - mBcl-2A1 + Bmf BH3 peptide <br />
**[[2voh]] - mBcl-2A1 + Bak BH3 peptide <br />
**[[2voh]] - mBcl-2A1 + Bak BH3 peptide <br />
**[[2voi]] - mBcl-2A1 + BID BH3 peptide <br />
**[[2voi]] - mBcl-2A1 + BID BH3 peptide <br />
-
**[[3mqp]] - hBcl-2A1 + Noxa BH3 peptide <br />
+
 
-
**[[5uul]] - hBcl-2A1 + PUMA BH3 peptide <br />
+
-
**[[5uuk]], [[5uup]] - hBcl-2A1 + Bfl-1 peptide <br />
+
-
**[[4zeq]] - hBcl-2A1 + BID BH3 peptide <br />
+
*Bcl-3
*Bcl-3
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*Bcl-6
*Bcl-6
-
**[[3e4u]], [[1r28]], [[1r29]], [[4u2m]] – hBcl-6 BTB domain <br />
+
**[[3e4u]], [[1r28]], [[1r29]], [[4u2m]], [[6xwf]] – hBcl-6 BTB domain 6-129 <br />
**[[3lbz]], [[5mw6]], [[5mw2]], [[5mwd]], [[5n1x]], [[5n1z]], [[5n20]], [[5n21]], [[5x4m]], [[5x4n]], [[5x4o]], [[5x4p]], [[5x9o]], [[5x9p]], [[5x4o]], [[5x4q]], [[6ew8]], [[6ew7]], [[6ew6]], [[6c3n]] – hBcl-6 BTB domain + inhibitor<br />
**[[3lbz]], [[5mw6]], [[5mw2]], [[5mwd]], [[5n1x]], [[5n1z]], [[5n20]], [[5n21]], [[5x4m]], [[5x4n]], [[5x4o]], [[5x4p]], [[5x9o]], [[5x9p]], [[5x4o]], [[5x4q]], [[6ew8]], [[6ew7]], [[6ew6]], [[6c3n]] – hBcl-6 BTB domain + inhibitor<br />
**[[6cq1]], [[6c3l]] – hBcl-6 BTB domain (mutant) + inhibitor<br />
**[[6cq1]], [[6c3l]] – hBcl-6 BTB domain (mutant) + inhibitor<br />
**[[4cp3]] – hBcl-6 BTB domain + antibiotic<br />
**[[4cp3]] – hBcl-6 BTB domain + antibiotic<br />
 +
**[[6xxs]], [[6xyx]], [[6xzz]], [[6zbu]] – hBcl-6 BTB domain + corepressor peptide<br />
**[[3bim]] – hBcl-6 BTB domain (mutant) + Bcl-6 corepressor<br />
**[[3bim]] – hBcl-6 BTB domain (mutant) + Bcl-6 corepressor<br />
**[[5h7g]], [[5h7h]] – hBcl-6 BTB domain + F1324 peptide<br />
**[[5h7g]], [[5h7h]] – hBcl-6 BTB domain + F1324 peptide<br />
Line 89: Line 98:
*Bcl-9
*Bcl-9
-
**[[3sl9]] – hBcl-9 residues 344-396 + catenin β-1<br />
+
**[[3sl9]] – hBcl-9 residues 344-396 + catenin beta-1<br />
-
**[[2gl7]] – hBcl-9 residues 344-396 + catenin β-1 + transcription factor 7-like<br />
+
**[[2gl7]] – hBcl-9 residues 344-396 + catenin beta-1 + transcription factor 7-like<br />
*Bcl-10
*Bcl-10
Line 109: Line 118:
**[[4cin]] - hBcl-W + BH3 peptide<br />
**[[4cin]] - hBcl-W + BH3 peptide<br />
-
*Bcl-2-like protein 4 (Bax)
+
*Bcl-2-like protein 4 (Bax or apoptosis regulator Bax)
**[[4bd7]], [[4s0o]], [[4s0p]] - hBax <br />
**[[4bd7]], [[4s0o]], [[4s0p]] - hBax <br />
-
**[[4bd8]], [[5w60]], [[5w61]] – hBax (mutant) <br />
+
**[[4bd8]], [[5w60]], [[5w61]], [[6eb6]] – hBax (mutant) <br />
 +
**[[6l8v]] - hBax helix2-helix5 - NMR<br />
**[[2lr1]] - hBax + VMIA peptide<br />
**[[2lr1]] - hBax + VMIA peptide<br />
**[[4bd6]] – hBax (mutant) + BH3 peptide<br />
**[[4bd6]] – hBax (mutant) + BH3 peptide<br />
Line 126: Line 136:
*Bcl-2-like protein 7 (Bak, Bcl-2 homologous antagonist/killer)
*Bcl-2-like protein 7 (Bak, Bcl-2 homologous antagonist/killer)
-
**[[2yv6]], [[2imt]], [[2jcn]], [[2ims]] – hBak<br />
+
**[[2yv6]], 2imt, 2jcn, 2ims, [[6odh]], [[7k02]] – hBak<br />
**[[5fmi]], [[4u2u]], [[5vx1]] – hBak (mutant)<br />
**[[5fmi]], [[4u2u]], [[5vx1]] – hBak (mutant)<br />
**[[4u2v]] – hBak/GFP<br />
**[[4u2v]] – hBak/GFP<br />
**[[3qbr]] - hBak + sjA<br />
**[[3qbr]] - hBak + sjA<br />
 +
**[[6uxm]], [[6uxn]], [[6uxo]], [[6uxp]], [[6uxq]], [[6uxr]] - hBak + inhibitor<br />
**[[2xpx]] - hBak fragment + BHRF1<br />
**[[2xpx]] - hBak fragment + BHRF1<br />
**[[5vwx]], [[5vwy]], [[5vwz]], [[5vx0]] - hBak + BIM BH3 domain<br />
**[[5vwx]], [[5vwy]], [[5vwz]], [[5vx0]] - hBak + BIM BH3 domain<br />
**[[5vwv]] - hBak (mutant)+ BIM BH3 domain<br />
**[[5vwv]] - hBak (mutant)+ BIM BH3 domain<br />
**[[2m5b]] - hBak + BID BH3 domain - NMR<br />
**[[2m5b]] - hBak + BID BH3 domain - NMR<br />
 +
**[[6mcy]] – mBak<br />
*Bcl-2-like protein 10
*Bcl-2-like protein 10
-
**[[2kua]] – mBcl-2-L-10<br />
 
**[[4b4s]] - hBcl-2-L-10 + hBIM BH3 peptide<br />
**[[4b4s]] - hBcl-2-L-10 + hBIM BH3 peptide<br />
 +
**[[2kua]] – mBcl-2-L-10<br />
 +
**[[6fbx]], [[6h1n]] – Bcl-2-L-10 - zebrafish<br />
-
*Bcl-2-like protein 11 (BIM)
+
*Bcl-2-like protein 11 (Bim)
-
**[[2nl9]] – hBIM + Mcl-1<br />
+
**[[2nl9]] – hBim + Mcl-1<br />
 +
**[[6x8o]] – hBim BH3 peptide<br />
-
*Mcl-1 (Bcl-2-like protein 3)
+
Mcl-1 (Bcl-2-like protein 3 or Myeloid cell leukemia-1)
-
**[[1wsx]] – mMcl-1 residues 152-308 - NMR<br />
 
-
**[[6dm8]] - mMcl-1/MBP + inhibitor<br />
 
**[[3mk8]] - hMcl-1 residues 174-324<br />
**[[3mk8]] - hMcl-1 residues 174-324<br />
**[[2mhs]] - hMcl-1 residues 174-324 (mutant)<br />
**[[2mhs]] - hMcl-1 residues 174-324 (mutant)<br />
Line 155: Line 167:
**[[4wmu]], [[4wmt]] - hMcl-1/MBP (mutant) + ligand<br />
**[[4wmu]], [[4wmt]] - hMcl-1/MBP (mutant) + ligand<br />
**[[4wgi]] - hMcl-1/MBP (mutant) + macrolactam<br />
**[[4wgi]] - hMcl-1/MBP (mutant) + macrolactam<br />
-
**[[3wix]], [[3wiy]], [[4oq5]], [[4oq6]], [[4hw2]], [[4hw3]], [[4hw4]], [[4wmr]], [[4zbf]], [[4zbi]], [[5fc4]], [[5fdo]], [[5fdr]], [[5iez]], [[5if4]], [[5jsb]], [[5ku9]], [[5vkc]], [[6b4l]], [[6b4u]], [[6bw2]], [[6bw8]], [[6fs1]], [[6fs2]] - hMcl-1 residues 174-324 + inhibitor<br />
+
**[[3wix]], [[3wiy]], [[4oq5]], [[4oq6]], [[4hw2]], [[4hw3]], [[4hw4]], [[4wmr]], [[4zbf]], [[4zbi]], [[5fc4]], [[5fdo]], [[5fdr]], [[5iez]], [[5if4]], [[5jsb]], [[5ku9]], [[5vkc]], [[6b4l]], [[6b4u]], [[6bw2]], [[6bw8]], [[6fs1]], [[6fs2]], [[6ne5]], [[6o4u]], [[6o6f]], [[6oqb]], [[6oqc]], [[6oqd]], [[6oqn]], [[6p3p]], [[6qgd]], [[6qfq]], [[6qyp]], [[6qz5]], [[6qz6]], [[6qz8]], [[6qzb]], [[6u63]], [[6u64]], [[6u65]], [[6u67]], [[6u6f]], [[6ud2]], [[6udi]], [[6udt]], [[6udu]], [[6udv]], [[6udx]], [[6udy]], [[6ybg]] - hMcl-1 residues 174-324 + inhibitor<br />
-
**[[5uum]] - hMcl-1 residues 174-324 + FS2 peptide <br />
+
**[[6ovc]] - hMcl-1 residues 174-324 + inhibitor - NMR<br />
-
**[[6mbd]] - hMcl-1 residues 174-324 + DM1 peptide <br />
+
**[[6qxj]], [[6qyk]], [[6qyl]], [[6qyn]], [[6qyo]], [[6qz7]], [[6ybj]], [[6ybk]], [[6ybl]] - hMcl-1 residues 174-324/MBP + inhibitor<br />
-
**[[6mbe]] - hMcl-1 residues 174-324 + DM7 peptide <br />
+
**[[5c3f]], [[5uum]], [[6mbb]], [[6mbc]], [[6mbd]], [[6mbe]], [[6qfm]], [[6ua3]], [[6uab]] - hMcl-1 residues 174-324 + peptide <br />
-
**[[5c3f]] - hMcl-1 residues 174-324 + BIB MM <br />
+
**[[6qb3]], [[6qfc]] - hMcl-1 residues 174-324 + scFv <br />
-
**[[5mes]], [[5mev]], [[6fs0]] - hMcl-1 residues 153-221 + inhibitor + antibody<br />
+
**[[6qb4]] - hMcl-1 residues 174-324 + scFv + inhibitor<br />
 +
**[[6qb6]] - hMcl-1 residues 174-324 + antibody <br />
 +
**[[6zie]] - hMcl-1 residues 174-324 + alphabody <br />
 +
**[[5mes]], [[5mev]] - hMcl-1 residues 153-221 + inhibitor + antibody<br />
**[[6fs0]] - hMcl-1 residues 174-324 + inhibitor + antibody<br />
**[[6fs0]] - hMcl-1 residues 174-324 + inhibitor + antibody<br />
 +
**[[1wsx]] – mMcl-1 residues 152-308 - NMR<br />
 +
**[[6dm8]] - mMcl-1/MBP + inhibitor<br />
*Mcl-1 complex with BH3 domain peptide
*Mcl-1 complex with BH3 domain peptide
Line 173: Line 190:
**[[4bpj]], [[4bpi]] - hMcl-1 fragment + Puma BH3 peptide <br />
**[[4bpj]], [[4bpi]] - hMcl-1 fragment + Puma BH3 peptide <br />
**[[5c6h]] - hMcl-1 fragment + Mule BH3 peptide <br />
**[[5c6h]] - hMcl-1 fragment + Mule BH3 peptide <br />
-
**[[5w89]], [[5w8f]], [[3kj0]], [[3kj1]], [[3kj2]], [[3io9]], [[3d7v]], [[2pqk]], [[5vx2]] - hMcl-1 fragment + BIM BH3 peptide <br />
+
**[[5w89]], [[5w8f]], 3kj0, 3kj1, 3kj2, 3io9, 3d7v, 2pqk, [[5vx2]], [[6qfi]] - hMcl-1 fragment + BIM BH3 peptide <br />
**[[2kbw]] - hMcl-1 fragment + BID BH3 peptide - NMR <br />
**[[2kbw]] - hMcl-1 fragment + BID BH3 peptide - NMR <br />
Line 186: Line 203:
**[[2i39]] – VvN1L – Vaccinia virus<br />
**[[2i39]] – VvN1L – Vaccinia virus<br />
**[[4bbb]], [[4bbc]], [[4bbd]] – VvN1L (mutant)<br />
**[[4bbb]], [[4bbc]], [[4bbd]] – VvN1L (mutant)<br />
 +
}}
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 08:20, 2 May 2021

3D structures of B-cell lymphoma proteins

Updated on 02-May-2021


Mcl-1 (Bcl-2-like protein 3 or Myeloid cell leukemia-1)

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel

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