7nuu
From Proteopedia
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==Crystal structure of human AMDHD2 in complex with Zn== | ==Crystal structure of human AMDHD2 in complex with Zn== | ||
| - | <StructureSection load='7nuu' size='340' side='right'caption='[[7nuu]]' scene=''> | + | <StructureSection load='7nuu' size='340' side='right'caption='[[7nuu]], [[Resolution|resolution]] 1.84Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NUU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NUU FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7nuu]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NUU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NUU FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nuu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nuu OCA], [https://pdbe.org/7nuu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nuu RCSB], [https://www.ebi.ac.uk/pdbsum/7nuu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nuu ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/N-acetylglucosamine-6-phosphate_deacetylase N-acetylglucosamine-6-phosphate deacetylase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.25 3.5.1.25] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nuu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nuu OCA], [https://pdbe.org/7nuu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nuu RCSB], [https://www.ebi.ac.uk/pdbsum/7nuu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nuu ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/NAGA_HUMAN NAGA_HUMAN]] Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6-phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. Although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded.<ref>PMID:22692205</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Baumann U]] | + | [[Category: N-acetylglucosamine-6-phosphate deacetylase]] |
| - | [[Category: Denzel | + | [[Category: Baumann, U]] |
| - | [[Category: Kroef V]] | + | [[Category: Denzel, M S]] |
| - | [[Category: Ruegenberg S]] | + | [[Category: Kroef, V]] |
| + | [[Category: Ruegenberg, S]] | ||
| + | [[Category: Amdhd2]] | ||
| + | [[Category: Amidohydrolase domain-containing protein 2]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Naga]] | ||
Revision as of 09:16, 5 May 2021
Crystal structure of human AMDHD2 in complex with Zn
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