1ed3

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[[Image:1ed3.gif|left|200px]]
[[Image:1ed3.gif|left|200px]]
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{{Structure
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{{STRUCTURE_1ed3| PDB=1ed3 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ed3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ed3 OCA], [http://www.ebi.ac.uk/pdbsum/1ed3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ed3 RCSB]</span>
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'''CRYSTAL STRUCTURE OF RAT MINOR HISTOCOMPATIBILITY ANTIGEN COMPLEX RT1-AA/MTF-E.'''
'''CRYSTAL STRUCTURE OF RAT MINOR HISTOCOMPATIBILITY ANTIGEN COMPLEX RT1-AA/MTF-E.'''
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[[Category: Stevens, J.]]
[[Category: Stevens, J.]]
[[Category: Wilson, I A.]]
[[Category: Wilson, I A.]]
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[[Category: cell surface receptor]]
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[[Category: Cell surface receptor]]
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[[Category: cellular immunity]]
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[[Category: Cellular immunity]]
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[[Category: immunology]]
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[[Category: Immunology]]
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[[Category: major histocompatibility complex]]
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[[Category: Major histocompatibility complex]]
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[[Category: mhc]]
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[[Category: Mhc]]
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[[Category: peptide antigen presentation]]
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[[Category: Peptide antigen presentation]]
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[[Category: rat minor histocompatibility complex]]
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[[Category: Rat minor histocompatibility complex]]
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[[Category: t cell receptor ligand]]
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[[Category: T cell receptor ligand]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:57:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:00:07 2008''
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Revision as of 11:57, 2 May 2008

Image:1ed3.gif

Template:STRUCTURE 1ed3

CRYSTAL STRUCTURE OF RAT MINOR HISTOCOMPATIBILITY ANTIGEN COMPLEX RT1-AA/MTF-E.


Overview

The rat MHC class Ia molecule RT1-Aa has the unusual capacity to bind long peptides ending in arginine, such as MTF-E, a thirteen-residue, maternally transmitted minor histocompatibility antigen. The antigenic structure of MTF-E was unpredictable due to its extraordinary length and two arginines that could serve as potential anchor residues. The crystal structure of RT1-Aa-MTF-E at 2.55 A shows that both peptide termini are anchored, as in other class I molecules, but the central residues in two independent pMHC complexes adopt completely different bulged conformations based on local environment. The MTF-E epitope is fully exposed within the putative T cell receptor (TCR) footprint. The flexibility demonstrated by the MTF-E structures illustrates how different TCRs may be raised against chemically identical, but structurally dissimilar, pMHC complexes.

About this Structure

1ED3 is a Protein complex structure of sequences from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Two different, highly exposed, bulged structures for an unusually long peptide bound to rat MHC class I RT1-Aa., Speir JA, Stevens J, Joly E, Butcher GW, Wilson IA, Immunity. 2001 Jan;14(1):81-92. PMID:11163232 Page seeded by OCA on Fri May 2 14:57:05 2008

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