1n3g
From Proteopedia
(Difference between revisions)
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<StructureSection load='1n3g' size='340' side='right'caption='[[1n3g]], [[NMR_Ensembles_of_Models | 29 NMR models]]' scene=''> | <StructureSection load='1n3g' size='340' side='right'caption='[[1n3g]], [[NMR_Ensembles_of_Models | 29 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
- | <table><tr><td colspan='2'>[[1n3g]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1n3g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N3G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N3G FirstGlance]. <br> |
- | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n3g OCA], [https://pdbe.org/1n3g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n3g RCSB], [https://www.ebi.ac.uk/pdbsum/1n3g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n3g ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
- | [[ | + | [[https://www.uniprot.org/uniprot/RAIA_ECOLI RAIA_ECOLI]] During stationary phase, prevents 70S dimer formation, probably in order to regulate translation efficiency during transition between the exponential and the stationary phases. In addition, during environmental stress such as cold shock or excessive cell density at stationary phase, stabilizes the 70S ribosome against dissociation, inhibits translation initiation and increase translation accuracy. When normal growth conditions are restored, is quickly released from the ribosome. Inhibits translation initiation by blocking the A-site (aminoacyl-tRNA site) and P-site (peptidyl-tRNA site) of the ribosome. Counteracts miscoding (translation errors) particularly efficiently at magnesium concentrations close to those observed in vivo but less efficiently at higher concentrations. Counteraction of miscoding was shown to be stronger than inhibition of translation, suggesting that the former activity could be the main function of RaiA in vivo.<ref>PMID:10535924</ref> <ref>PMID:11168583</ref> <ref>PMID:11375931</ref> <ref>PMID:15219834</ref> <ref>PMID:16324148</ref> <ref>PMID:15502846</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] |
Revision as of 09:32, 5 May 2021
Solution structure of the ribosome-associated cold shock response protein Yfia of Escherichia coli
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