1ao7

From Proteopedia

---

Revision as of 13:54, 12 November 2007

proteopedia linkproteopedia link

spinqualitylabelsall models 1ao7, resolution 2.6Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

COMPLEX BETWEEN HUMAN T-CELL RECEPTOR, VIRAL PEPTIDE (TAX), AND HLA-A 0201

Contents 1 Overview 2 Disease 3 About this Structure 4 Reference

Overview

Recognition by a T-cell antigen receptor (TCR) of peptide complexed with a, major histocompatibility complex (MHC) molecule occurs through variable, loops in the TCR structure which bury almost all the available peptide and, a much larger area of the MHC molecule. The TCR fits diagonally across the, MHC peptide-binding site in a surface feature common to all class I and, class II MHC molecules, providing evidence that the nature of binding is, general. A broadly applicable binding mode has implications for the, mechanism of repertoire selection and the magnitude of alloreactions.

Disease

Known diseases associated with this structure: Abacavir hypersensitivity, susceptibility to OMIM:[142800], Ankylosing spondylitis, susceptibility to, 1 OMIM:[142800], Hypoproteinemia, hypercatabolic OMIM:[109700], Stevens-Johnson syndrome, susceptibility to OMIM:[142800]

About this Structure

1AO7 is a Protein complex structure of sequences from Homo sapiens and Human t-lymphotropic virus 1 with EMC as ligand. Full crystallographic information is available from OCA.

Reference

Structure of the complex between human T-cell receptor, viral peptide and HLA-A2., Garboczi DN, Ghosh P, Utz U, Fan QR, Biddison WE, Wiley DC, Nature. 1996 Nov 14;384(6605):134-41. PMID:8906788

Page seeded by OCA on Mon Nov 12 16:00:31 2007