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Beta-lactamase 3D structures

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Line 29: Line 29:
**[[3ni9]] - PaBlac A Ges-2<br />
**[[3ni9]] - PaBlac A Ges-2<br />
**[[1hzo]] – Blac A – ''Proteus vulgaris''<br />
**[[1hzo]] – Blac A – ''Proteus vulgaris''<br />
-
**[[1kge]], [[1kgf]], [[1kgg]], [[1ome]] – SaBlac A (mutant) - S''taphylococcus aureus''<br />
+
**[[1kge]], [[1kgf]], [[1kgg]], [[1ome]] – SaBlac A (mutant) - ''Staphylococcus aureus''<br />
**[[3blm]] – SaBlac A<br />
**[[3blm]] – SaBlac A<br />
**[[1mbl]], [[3ly3]], [[3soi]], [[4n92]], [[5ghx]], [[5zfl]] – BlBlac A (mutant) – ''Bacillus licheniformis''<br />
**[[1mbl]], [[3ly3]], [[3soi]], [[4n92]], [[5ghx]], [[5zfl]] – BlBlac A (mutant) – ''Bacillus licheniformis''<br />
Line 37: Line 37:
**[[3s4x]], [[5har]], [[5hai]] - EncBlac A (mutant) – ''Enterobacter cloacae''<br />
**[[3s4x]], [[5har]], [[5hai]] - EncBlac A (mutant) – ''Enterobacter cloacae''<br />
**[[3zdj]], [[4b88]] – Blac – precambrian<br />
**[[3zdj]], [[4b88]] – Blac – precambrian<br />
-
**[[4c6y]], [[4c75]], [[5fqm]], [[6tww]], [[6txd]], [[6ty6]] – Blac – synthetic<br />
+
**[[4c6y]], [[4c75]], [[5fqm]], [[6tww]], [[6txd]], [[6ty6]], [[6yrs]] – Blac – synthetic<br />
**[[5tfq]] – Blac – ''Bacterioides cellulosilyticus''<br />
**[[5tfq]] – Blac – ''Bacterioides cellulosilyticus''<br />
**[[5glc]], [[5gla]], [[5gl9]] - BtBlac A - ''Burkholderia thailandensis''<br />
**[[5glc]], [[5gla]], [[5gl9]] - BtBlac A - ''Burkholderia thailandensis''<br />
Line 49: Line 49:
**[[6w34]] – BcBlac A (mutant) - ''Bacillus cereus''<br />
**[[6w34]] – BcBlac A (mutant) - ''Bacillus cereus''<br />
**[[6wip]] – Blac A – ''Micromonospora aurantiaca''<br />
**[[6wip]] – Blac A – ''Micromonospora aurantiaca''<br />
 +
**[[6l3s]] – MmBlac Imp-27 – ''Morganella morganii''<br />
*β-lactamase class A binary complex
*β-lactamase class A binary complex
Line 69: Line 70:
**[[3nia]] - PaBlac A Ges-2 + inhibitor - ''Pseudomonas aeruginosa'' <br />
**[[3nia]] - PaBlac A Ges-2 + inhibitor - ''Pseudomonas aeruginosa'' <br />
**[[6q35]] - PaBlac A Ges-5 + boronic acid inhibitor <br />
**[[6q35]] - PaBlac A Ges-5 + boronic acid inhibitor <br />
-
**[[3p98]] – Blac Tem-72 + citrate – ''Morganella morganii''<br />
+
**[[3p98]] – MmBlac Tem-72 + citrate <br />
**[[5tg7]], [[5tg6]], [[5tg5]], [[5tg4]] - AbBlac A + boronic acid inhibitor<br />
**[[5tg7]], [[5tg6]], [[5tg5]], [[5tg4]] - AbBlac A + boronic acid inhibitor<br />
**[[5gld]], [[5glb]] - BtBlac A + boronic acid inhibitor <br />
**[[5gld]], [[5glb]] - BtBlac A + boronic acid inhibitor <br />
Line 114: Line 115:
**[[3hre]], [[5kmt]], [[5kmu]], [[5kkf]] - EcESBL Ctx-M-9 (mutant)<br />
**[[3hre]], [[5kmt]], [[5kmu]], [[5kkf]] - EcESBL Ctx-M-9 (mutant)<br />
**[[4ua6]], [[6d7h]] – EcESBL Ctx-M-14 <br />
**[[4ua6]], [[6d7h]] – EcESBL Ctx-M-14 <br />
-
**[[1ylt]], [[5vth]], [[5twd]], [[6cyn]], [[6cyk]], [[6d7i]], [[6v5e]], [[6v6g]], [[6v6p]] - EcBlac A Ctx-M-14 (mutant)<br />
+
**[[1ylt]], [[5vth]], [[5twd]], [[6cyn]], [[6cyk]], [[6d7i]], [[6v5e]], [[6v6g]], [[6v6p]], [[7k2x]] - EcBlac A Ctx-M-14 (mutant)<br />
**[[4hbt]] – EcESBL Ctx-M-15<br />
**[[4hbt]] – EcESBL Ctx-M-15<br />
**[[1ylw]] - EcESBL Ctx-M-16<br />
**[[1ylw]] - EcESBL Ctx-M-16<br />
Line 140: Line 141:
**[[3g2y]], [[3g2z]], [[3g30]], [[3g31]], [[3g32]], [[3g34]], [[3g35]], [[4dds]], [[4ddy]], [[4de0]], [[4de1]], [[4de2]], [[4de3]], [[1yly]], [[1ym1]], [[1yms]] - EcBlac A Ctx-M-9 + inhibitor<br />
**[[3g2y]], [[3g2z]], [[3g30]], [[3g31]], [[3g32]], [[3g34]], [[3g35]], [[4dds]], [[4ddy]], [[4de0]], [[4de1]], [[4de2]], [[4de3]], [[1yly]], [[1ym1]], [[1yms]] - EcBlac A Ctx-M-9 + inhibitor<br />
**[[4len]] - EcESBL Ctx-M-9 (mutant) + inhibitor<br />
**[[4len]] - EcESBL Ctx-M-9 (mutant) + inhibitor<br />
-
**[[4uaa]], [[4ua7]], [[6md8]], [[6mia]], [[6mz1]], [[6mz2]] – EcESBL Ctx-M-14 + inhibitor<br />
+
**[[4uaa]], [[4ua7]], [[6md8]], [[6mia]], [[6mz1]], [[6mz2]], [[6ooe]], [[6oof]], [[6ooj]], [[6ook]] – EcESBL Ctx-M-14 + inhibitor<br />
-
**[[6bt6]], [[6v7t]], [[6v83]], [[6v8v]] – EcESBL Ctx-M-14 (mutant) + inhibitor<br />
+
**[[6bt6]], [[6v7h]], [[6v7t]], [[6v83]], [[6v8v]] – EcESBL Ctx-M-14 (mutant) + inhibitor<br />
**[[4ua9]], [[1ylz]] – EcESBL Ctx-M-14 + boronic acid inhibitor<br />
**[[4ua9]], [[1ylz]] – EcESBL Ctx-M-14 + boronic acid inhibitor<br />
**[[5vle]], [[5top]], [[5toy]], [[6vnu]] - EcESBL Ctx-M-14 (mutant) + ruthenium inhibitor<br />
**[[5vle]], [[5top]], [[5toy]], [[6vnu]] - EcESBL Ctx-M-14 (mutant) + ruthenium inhibitor<br />
**[[6unb]] – EcESBL Ctx-M-14 + antibiotic<br />
**[[6unb]] – EcESBL Ctx-M-14 + antibiotic<br />
 +
**[[7k2w]], [[7k2y]] – EcESBL Ctx-M-14 (mutant) + antibiotic<br />
**[[4xxr]], [[5u53]], [[5tw6]], [[5twe]] - EcESBL Ctx-M-14 (mutant) + antibiotic<br />
**[[4xxr]], [[5u53]], [[5tw6]], [[5twe]] - EcESBL Ctx-M-14 (mutant) + antibiotic<br />
**[[4hbu]], [[6sp6]] – EcESBL Ctx-M-15 + inhibitor<br />
**[[4hbu]], [[6sp6]] – EcESBL Ctx-M-15 + inhibitor<br />
Line 209: Line 211:
**[[4uam]], [[2fhx]], [[4bp0]], [[5nde]] - PaBlac Imp-1 <br />
**[[4uam]], [[2fhx]], [[4bp0]], [[5nde]] - PaBlac Imp-1 <br />
**[[4f6h]], [[4f6z]], [[5ls3]] – PaBlac Imp-1 (mutant)<br />
**[[4f6h]], [[4f6z]], [[5ls3]] – PaBlac Imp-1 (mutant)<br />
-
**[[6r79]] - PaBlac Imp-13 <br />
+
**[[6r79]], [[6yi4]] - PaBlac Imp-13 <br />
**[[5b3r]] - PaBlac Imp-18 <br />
**[[5b3r]] - PaBlac Imp-18 <br />
**[[5ev6]], [[5y5b]] - SmBlac Imp-1 – ''Serratia marcescens''<br />
**[[5ev6]], [[5y5b]] - SmBlac Imp-1 – ''Serratia marcescens''<br />
Line 223: Line 225:
**[[3l6n]] – Blac B – ''Chryseobacter indolegenes''<br />
**[[3l6n]] – Blac B – ''Chryseobacter indolegenes''<br />
**[[3r2u]] – SaBlac B<br />
**[[3r2u]] – SaBlac B<br />
-
**[[3rkj]], [[3sbl]], [[3sfp]], [[3spu]], [[3zr9]], [[3pg4]], [[6c6i]] - KpBlac B Ndm-1<br />
+
**[[3rkj]], [[3sbl]], [[3sfp]], [[3spu]], [[3zr9]], [[3pg4]], [[6c6i]], [[3srx]], [[4h0d]], [[6c6i]], [[5xp6]], [[5n0i]], [[5k4k]], [[5k4m]], [[5k4n]], [[5jqj]], [[5xp9]], [[5zgi]], [[5nbk]], [[[6cac]], [[6ex7]], [[6lhe]], [[6twt]] - KpBlac B Ndm-1 + metal ion<br />
-
**[[3srx]], [[6ex7]] - KpBlac B Ndm-1 + Cd <br />
+
**[[5zgf]], [[7ct2]] - KpBlac B Ndm-1 (mutant) + metal ion<br />
-
**[[4h0d]] - KpBlac B Ndm-1 + Mn<br />
+
-
**[[5xp6]], [[5n0i]], [[5k4m]], [[5jqj]], [[5zgi]], [[5nbk]], [[6twt]] - KpBlac B Ndm-1 + Zn<br />
+
-
**[[5zgf]] - KpBlac B Ndm-1 (mutant) + Zn<br />
+
-
**[[6cac]] - KpBlac B Ndm-1 + Zn + Co + Cd<br />
+
-
**[[5xp9]] - KpBlac B Ndm-1 + Bi<br />
+
**[[6mh0]] - KpBlac B Ndm-3 + Zn<br />
**[[6mh0]] - KpBlac B Ndm-3 + Zn<br />
**[[3rkk]], [[4gyq]], [[4gyu]] - KpBlac B Ndm-1 (mutant) <br />
**[[3rkk]], [[4gyq]], [[4gyu]] - KpBlac B Ndm-1 (mutant) <br />
Line 253: Line 250:
**[[4uwo]], [[4uwp]], [[4uwr]], [[4uws]] - KpBlac B Vim-26<br />
**[[4uwo]], [[4uwp]], [[4uwr]], [[4uws]] - KpBlac B Vim-26<br />
**[[4wd6]] – PsBlac Dim-1 – ''Pseudomonas stutzeri''<br />
**[[4wd6]] – PsBlac Dim-1 – ''Pseudomonas stutzeri''<br />
-
**[[5iqk]] – Blac – uncultured<br />
+
**[[5iqk]], [[7byq]], [[7bz1]], [[7bz3]], [[7bz4]], [[7bzi]] – Blac – uncultured<br />
**[[5ctn]], [[5ctm]] – Blac – ''Bacillus pumilus''<br />
**[[5ctn]], [[5ctm]] – Blac – ''Bacillus pumilus''<br />
**[[4ysb]] – Blac + Fe – ''Myxococcus xanthus''<br />
**[[4ysb]] – Blac + Fe – ''Myxococcus xanthus''<br />
Line 263: Line 260:
**[[6v54]], [[6v5m]], [[6v70]], [[6v71]] – HbBlac (mutant) – ''Hirschia baltica''<br />
**[[6v54]], [[6v5m]], [[6v70]], [[6v71]] – HbBlac (mutant) – ''Hirschia baltica''<br />
**[[6v72]], [[6v73]] – ElBlac – ''Erythrobacter litoralis''<br />
**[[6v72]], [[6v73]] – ElBlac – ''Erythrobacter litoralis''<br />
 +
**[[6jv4]] - VaBlac Vmb-1 – ''Vibrio alginolyticus''<br />
*β-lactamase class B binary complex with antibiotic
*β-lactamase class B binary complex with antibiotic
Line 275: Line 273:
**[[4rm5]] – KpBlac B Ndm-1 (mutant) + antibiotic<br />
**[[4rm5]] – KpBlac B Ndm-1 (mutant) + antibiotic<br />
**[[5ypi]], [[5ypk]], [[5ypl]], [[5ypm]], [[5ypn]] – EcBlac B Ndm-1 + antibiotic<br />
**[[5ypi]], [[5ypk]], [[5ypl]], [[5ypm]], [[5ypn]] – EcBlac B Ndm-1 + antibiotic<br />
-
**[[6lf4]] - Blac Vmb-1 + antibiotic – ''Vibrio alginolyticus''<br />
+
**[[6ol8]] – EcBlac B Ndm-12 + antibiotic<br />
 +
**[[6lf4]] - VaBlac Vmb-1 + antibiotic<br />
*β-lactamase class B binary complex
*β-lactamase class B binary complex
Line 283: Line 282:
**[[1jje]], [[1jjt]], [[3lce]], [[3wxc]], [[4c1f]], [[4c1g]], [[5ndb]] - PaBlac B Imp-1+ inhibitor<br />
**[[1jje]], [[1jjt]], [[3lce]], [[3wxc]], [[4c1f]], [[4c1g]], [[5ndb]] - PaBlac B Imp-1+ inhibitor<br />
**[[5n5h]] - PaBlac B Vim-1 + inhibitor<br />
**[[5n5h]] - PaBlac B Vim-1 + inhibitor<br />
-
**[[4c1d]], [[4c1e]], [[4pvo]], [[4pvt]], [[4ua4]], [[5lm6]], [[5le1]], [[5lch]], [[5lcf]], [[5lca]], [[5fqc]], [[5acx]], [[5acw]], [[5acv]], [[5acu]], [[5y6d]], [[5nhz]], [[5ni0]], [[5n4s]], [[5n4t]], [[5mxq]], [[5mxr]], [[5k48]], [[6hf5]], [[6ew3]], [[5y6e]], [[5o7n]], [[6dd0]], [[6dd1]], [[6j8r]], [[6kxo]], [[6kzn]], [[6sp7]], [[6v1p]] - PaBlac B Vim-2 + inhibitor<br />
+
**[[4c1d]], [[4c1e]], [[4pvo]], [[4pvt]], [[4ua4]], [[5lm6]], [[5le1]], [[5lch]], [[5lcf]], [[5lca]], [[5fqc]], [[5acx]], [[5acw]], [[5acv]], [[5acu]], [[5y6d]], [[5nhz]], [[5ni0]], [[5n4s]], [[5n4t]], [[5mxq]], [[5mxr]], [[5k48]], [[6hf5]], [[6ew3]], [[5y6e]], [[5o7n]], [[6dd0]], [[6dd1]], [[6j8r]], [[6kxo]], [[6kzn]], [[6sp7]], [[6v1p]], [[6zyn]], [[6zyo]], [[6zyp]] - PaBlac B Vim-2 + inhibitor<br />
**[[6ibs]], [[6ibv]], [[6jn6]], [[6o5t]], [[6rpn]] - PaBlac B Vim-2 + boronic acid inhibitor<br />
**[[6ibs]], [[6ibv]], [[6jn6]], [[6o5t]], [[6rpn]] - PaBlac B Vim-2 + boronic acid inhibitor<br />
**[[5n55]], [[5n58]] - PaBlac B Vim-5 + inhibitor<br />
**[[5n55]], [[5n58]] - PaBlac B Vim-5 + inhibitor<br />
Line 292: Line 291:
**[[6k4t]], [[6k4x]] - SmBlac Smb-1+ inhibitor<br />
**[[6k4t]], [[6k4x]] - SmBlac Smb-1+ inhibitor<br />
**[[2doo]] - SmBlac Imp-1+ fluorescent agent<br />
**[[2doo]] - SmBlac Imp-1+ fluorescent agent<br />
-
**[[2fu8]], [[2fu9]], [[2gfj]], [[2gfk]], [[2hb9]], [[2qdt]], [[5dpx]] - StmBlac B + inhibitor<br />
+
**[[2fu8]], [[2fu9]], [[2gfj]], [[2gfk]], [[2hb9]], [[2qdt]], [[5dpx]], [[5evk]], [[5evd]], [[5evb]], [[5hh6]], [[5hh5]] - StmBlac B L1 , [[6xbe]], [[6xbf]], [[6zyq]]+ inhibitor<br />
**[[3iof]], [[1x8i]], [[3iog]]– AhBlac B (mutant) + inhibitor<br />
**[[3iof]], [[1x8i]], [[3iog]]– AhBlac B (mutant) + inhibitor<br />
**[[1x8g]], [[2gkl]], [[2qds]] – AhBlac B + inhibitor<br />
**[[1x8g]], [[2gkl]], [[2qds]] – AhBlac B + inhibitor<br />
Line 299: Line 298:
**[[5ew0]] - SfBlac B + inhibitor<br />
**[[5ew0]] - SfBlac B + inhibitor<br />
**[[3q6v]] – SfBlac B + glycerol <br />
**[[3q6v]] – SfBlac B + glycerol <br />
-
**[[4exy]], [[4exs]], [[4eyl]], [[4hky]], [[4ram]], [[4raw]], [[4rbs]], [[4rl0]], [[4rl2]], [[4u4l]], [[5a5z]], [[5n0h]], [[5zjc]], [[5zj8]], [[5zj7]], [[5zj2]], [[5zj1]], [[5zio]], [[5zh1]], [[5zgz]], [[5zgy]], [[5zgx]], [[5zgw]], [[5zgv]], [[5zgu]], [[5zgt]], [[5zgr]], [[5zgq]], [[5zgp]], [[6d1a]], [[6d1b]], [[6d1c]], [[6d1d]], [[6d1e]], [[6d1f]], [[6d1g]], [[6d1h]], [[6d1i]], [[6d1j]], [[6d1k]], [[6efj]], [[6mdu]], [[6ny7]], [[6rmf], [[6v1m]] – KpBlac B Ndm-1+ inhibitor<br />
+
**[[4exy]], [[4exs]], [[4eyl]], [[4hky]], [[4ram]], [[4raw]], [[4rbs]], [[4rl0]], [[4rl2]], [[4u4l]], [[5a5z]], [[5n0h]], [[5zjc]], [[5zj8]], [[5zj7]], [[5zj2]], [[5zj1]], [[5zio]], [[5zh1]], [[5zgz]], [[5zgy]], [[5zgx]], [[5zgw]], [[5zgv]], [[5zgu]], [[5zgt]], [[5zgr]], [[5zgq]], [[5zgp]], [[6d1a]], [[6d1b]], [[6d1c]], [[6d1d]], [[6d1e]], [[6d1f]], [[6d1g]], [[6d1h]], [[6d1i]], [[6d1j]], [[6d1k]], [[6efj]], [[6mdu]], [[6ny7]], [[6rmf], [[6v1m]], [[6xbe]], [[6xbf]], [[6zyq]] – KpBlac B Ndm-1+ inhibitor<br />
**[[6o3r]] – KpBlac B Ndm-1 (mutant) + inhibitor<br />
**[[6o3r]] – KpBlac B Ndm-1 (mutant) + inhibitor<br />
**[[6q2y]], [[6q30]] – KpBlac B Ndm-1 + boronic acid inhibitor<br />
**[[6q2y]], [[6q30]] – KpBlac B Ndm-1 + boronic acid inhibitor<br />
Line 311: Line 310:
*'''β-lactamase class C'''
*'''β-lactamase class C'''
-
**[[5f1g]], [[5ggw]], [[6g9t]] – EcBlac C<br />
+
**[[5f1g]], [[5ggw]], [[6g9t]], [[6xg1]] – EcBlac C<br />
**[[3fkw]], [[3iwi]], [[3iwo]], [[3iwq]], [[3ixd]] – EcBlac C (mutant) <br />
**[[3fkw]], [[3iwi]], [[3iwo]], [[3iwq]], [[3ixd]] – EcBlac C (mutant) <br />
**[[1zkj]], [[5f1f]], [[5k1d]], [[5gsc]] – EaBlac C – ''Enterobacter aerogenes''<br />
**[[1zkj]], [[5f1f]], [[5k1d]], [[5gsc]] – EaBlac C – ''Enterobacter aerogenes''<br />
**[[2qz6]] – Blac C – ''Pseudomonas fluorescens''<br />
**[[2qz6]] – Blac C – ''Pseudomonas fluorescens''<br />
-
**[[3w8k]], [[6k8x]] – KpBlac C<br />
+
**[[3w8k]], [[6k8x]], [[6m5p]] – KpBlac C<br />
 +
**[[6m5h]], [[6m5q]] – KpBlac C (mutant)<br />
**[[4u0t]] – AbBlac C Adc-7<br />
**[[4u0t]] – AbBlac C Adc-7<br />
**[[4qd4]] – AbBlac C Adc-68<br />
**[[4qd4]] – AbBlac C Adc-68<br />
Line 336: Line 336:
**[[2wzx]], [[2wzz]], [[6i30]] – PaBlac C + inhibitor<br />
**[[2wzx]], [[2wzz]], [[6i30]] – PaBlac C + inhibitor<br />
**[[4ooy]] - PaBlac C + antibiotic<br />
**[[4ooy]] - PaBlac C + antibiotic<br />
-
**[[4u0x]], [[5wac]], [[5wad]], [[5wae]], [[5waf]], [[5wag]], [[5w12]], [[5w13]], [[5w14]], [[6wif]] - AbBlac C Adc-7 + boronic acid inhibitor <br />
+
**[[4u0x]], [[5wac]], [[5wad]], [[5wae]], [[5waf]], [[5wag]], [[5w12]], [[5w13]], [[5w14]], [[6tzf]], [[6tzg]], [[6tzi]], [[6tzj]], [[6wif]] - AbBlac C Adc-7 + boronic acid inhibitor <br />
 +
**[[6pwm]] - AbBlac C + antibiotic<br />
**[[6fm7]] - AeBlac C Tru-1 + inhibitor <br />
**[[6fm7]] - AeBlac C Tru-1 + inhibitor <br />
**[[5k1f]] - EaBlac C + inhibitor <br />
**[[5k1f]] - EaBlac C + inhibitor <br />
Line 351: Line 352:
**[[1m6k]] – EcBlac D<br />
**[[1m6k]] – EcBlac D<br />
**[[3if6]], [[4s2p]] - KpBlac D Oxa-46<br />
**[[3if6]], [[4s2p]] - KpBlac D Oxa-46<br />
-
**[[3hbr]] – KpBlac D Oxa-48<br />
+
**[[3hbr]], [[6hoo]], [[7ass]] – KpBlac D Oxa-48<br />
**[[6i5d]], [[6rj7]] - KpBlac D Oxa-48 (mutant)<br />
**[[6i5d]], [[6rj7]] - KpBlac D Oxa-48 (mutant)<br />
**[[6huh]] - KpBlac D Oxa-427<br />
**[[6huh]] - KpBlac D Oxa-427<br />
Line 358: Line 359:
**[[4zdx]] - AbBlac D Oxa-51<br />
**[[4zdx]] - AbBlac D Oxa-51<br />
**[[4y0o]] - AbBlac D Oxa-58<br />
**[[4y0o]] - AbBlac D Oxa-58<br />
 +
**[[6t1h]] - AbBlac D Oxa-66<br />
**[[6nz8]] - AbBlac D Oxa-231<br />
**[[6nz8]] - AbBlac D Oxa-231<br />
**[[4s2l]], [[5odz]] - EncBlac D Oxa-163<br />
**[[4s2l]], [[5odz]] - EncBlac D Oxa-163<br />
-
**[[5e2f]] – BsBlac D <br />
+
**[[5e2f]], [[6w5e]] – BsBlac D <br />
**[[4ied]] – Blac – ''Fusobacterium nucleatum''<br />
**[[4ied]] – Blac – ''Fusobacterium nucleatum''<br />
**[[6nlw]] – Blac D – ''Shewanella oneidensis''<br />
**[[6nlw]] – Blac D – ''Shewanella oneidensis''<br />
Line 369: Line 371:
**[[6ue2]] – Blac D – ''Peptoclostridium difficile''<br />
**[[6ue2]] – Blac D – ''Peptoclostridium difficile''<br />
**[[6wy4]] – CdBlac D – ''Clostridium difficile''<br />
**[[6wy4]] – CdBlac D – ''Clostridium difficile''<br />
 +
**[[6w5g]] – BaBlac D – ''Bacillus atrophaeus''<br />
 +
**[[6w5o]] – BaBlac D (mutant) <br />
*β-lactamase class D binary complex
*β-lactamase class D binary complex
Line 392: Line 396:
**[[4mll]] - KpBlac D Oxa-1 + antibiotic<br />
**[[4mll]] - KpBlac D Oxa-1 + antibiotic<br />
**[[4s2j]], [[4s2k]], [[4s2n]], [[4wmc]], [[6pqi]], [[6psg]], [[6pt1]], [[6pt5]], [[6ptu]] - KpBlac D Oxa-48 + antibiotic<br />
**[[4s2j]], [[4s2k]], [[4s2n]], [[4wmc]], [[6pqi]], [[6psg]], [[6pt1]], [[6pt5]], [[6ptu]] - KpBlac D Oxa-48 + antibiotic<br />
-
**[[6pxx]] - KpBlac D Oxa-48 (mutant) + antibiotic<br />
+
**[[6pxx]], [[7kh9]] - KpBlac D Oxa-48 (mutant) + antibiotic<br />
 +
**[[7khy]] - KpBlac D Oxa-163 + antibiotic<br />
 +
**[[6xj3]] - KpBlac D + antibiotic<br />
*'''AmpC β-lactamase'''
*'''AmpC β-lactamase'''
-
**[[1ke4]], [[2bls]], [[2zj9]], [[3bls]], [[5gzw]] – EcBlac<br />
+
**[[1ke4]], [[2bls]], [[2zj9]], [[3bls]], [[5gzw]], [[6t3d]] – EcBlac<br />
**[[1l0d]], [[1l0e]], [[1l0f]], [[1l0g]], [[4kg6]], [[5joc]] - EcBlac (mutant)
**[[1l0d]], [[1l0e]], [[1l0f]], [[1l0g]], [[4kg6]], [[5joc]] - EcBlac (mutant)
 +
**[[6lc7]] - EncBlac <br />
 +
**[[4gzb]], [[4wz4]], [[4wyy]] – PaBlac<br />
 +
**[[4net]] – AbBlac<br />
 +
**[[5e2h]] – Blac – ''Mycobacterium smegmatis''<br />
 +
**[[5e2g]] – Blac – ''Burkholderia cenocepacia''<br />
 +
 +
*AmpC -lactamase binary complex
 +
**[[1fcn]] – EcBlac (mutant) + substrate<br />
**[[1fcn]] – EcBlac (mutant) + substrate<br />
 +
**[[1iel]], [[1fcm]], [[1iem]], [[1kvm]], [[1ll5]], [[1ll9]], [[1llb]], [[4kz3]], [[4kz4]], [[4okp]], [[4olg]], [[4jxg]], [[6t35]], [[6t5y]], [[6tbw]] - EcBlac + antibiotic<br />
**[[1fco]], [[1i5q]], [[1kvl]], [[4ken]], [[4kg2]], [[4kg5]], [[4kg6]], [[4kz3]], [[4kz4]], [[4kg9]], [[4kz5]], [[4kz6]], [[4kz7]], [[4kz8]], [[4kza]], [[4kzb]] - EcBlac (mutant) + antibiotic<br />
**[[1fco]], [[1i5q]], [[1kvl]], [[4ken]], [[4kg2]], [[4kg5]], [[4kg6]], [[4kz3]], [[4kz4]], [[4kg9]], [[4kz5]], [[4kz6]], [[4kz7]], [[4kz8]], [[4kza]], [[4kzb]] - EcBlac (mutant) + antibiotic<br />
-
**[[1iel]], [[1fcm]], [[1iem]], [[1kvm]], [[1ll5]], [[1ll9]], [[1llb]], [[4kz3]], [[4kz4]], [[4okp]], [[4olg]], [[4jxg]] - EcBlac + antibiotic<br />
+
**[[1fsw]], [[1fsy]], [[1kds]], [[1kdw]], [[1ke0]], [[1ke3]], [[1mxo]], [[1my8]], [[4e3i]], [[4e3j]], [[4e3k]], [[4e3l]], [[4e3m]], [[4e3n]], [[4e3o]], [[2i72]], [[4lv0]], [[4lv1]], [[4lv2]], [[4lv3]], [[4oqg]], [[6yeo]], [[6ypd]], [[6t7l]], [[6tpm]] - EcBlac + boronic acid inhibitor<br />
-
**[[1fsw]], [[1fsy]], [[1kds]], [[1kdw]], [[1ke0]], [[1ke3]], [[1mxo]], [[1my8]], [[4e3i]], [[4e3j]], [[4e3k]], [[4e3l]], [[4e3m]], [[4e3n]], [[4e3o]], [[2i72]], [[4lv0]], [[4lv1]], [[4lv2]], [[4lv3]], [[4oqg]] - EcBlac + boronic acid inhibitor<br />
+
**[[1pi4]], [[1pi5]], [[2ffy]] - EcBlac (mutant) + boronic acid inhibitor<br />
**[[1pi4]], [[1pi5]], [[2ffy]] - EcBlac (mutant) + boronic acid inhibitor<br />
**[[1l2s]], [[1xgi]], [[1xgj]], [[2hdq]], [[2hdr]], [[2hds]], [[2hdu]], [[2p9v]], [[2pu2]], [[2pu4]], [[2r9w]], [[2r9x]], [[2rcx]], [[4jxs]], [[4jxv]], [[4jxw]], [[4old]], [[6dpz]], [[6dpy]], [[6dpx]], [[6dpt]] - EcBlac + inhibitor<br />
**[[1l2s]], [[1xgi]], [[1xgj]], [[2hdq]], [[2hdr]], [[2hds]], [[2hdu]], [[2p9v]], [[2pu2]], [[2pu4]], [[2r9w]], [[2r9x]], [[2rcx]], [[4jxs]], [[4jxv]], [[4jxw]], [[4old]], [[6dpz]], [[6dpy]], [[6dpx]], [[6dpt]] - EcBlac + inhibitor<br />
**[[4jxg]] – EcBlac + oxacillin<br />
**[[4jxg]] – EcBlac + oxacillin<br />
**[[1o07]], [[4kz9]] - EcBlac (mutant) + inhibitor<br />
**[[1o07]], [[4kz9]] - EcBlac (mutant) + inhibitor<br />
-
**[[6lc7]] - EncBlac <br />
 
**[[6lc8]], [[6lc9]] - EncBlac + inhibitor<br />
**[[6lc8]], [[6lc9]] - EncBlac + inhibitor<br />
**[[4xux]] - EncBlac + boronic acid inhibitor<br />
**[[4xux]] - EncBlac + boronic acid inhibitor<br />
Line 412: Line 425:
**[[3s1y]], [[3s22]] - PaBlac (mutant) + inhibitor<br />
**[[3s1y]], [[3s22]] - PaBlac (mutant) + inhibitor<br />
**[[6s1s]] - PaBlac + boronic acid inhibitor<br />
**[[6s1s]] - PaBlac + boronic acid inhibitor<br />
-
**[[4gzb]], [[4wz4]], [[4wyy]] – PaBlac<br />
 
-
**[[4net]] – AbBlac<br />
 
-
**[[5e2h]] – Blac – ''Mycobacterium smegmatis''<br />
 
-
**[[5e2g]] – Blac – ''Burkholderia cenocepacia''<br />
 
*'''Carbapenemase'''
*'''Carbapenemase'''
Line 422: Line 431:
**[[3fai]], [[1x8h]], [[3sw3]], [[3t9m]] - AhBlac B (mutant)<br />
**[[3fai]], [[1x8h]], [[3sw3]], [[3t9m]] - AhBlac B (mutant)<br />
**[[6p96]] - KpBlac Oxa-48 <br />
**[[6p96]] - KpBlac Oxa-48 <br />
-
**[[6p97]], [[6p98]], [[6p99]], [[6p9c]], [[6pk0]] - KpBlac Oxa-48 + antibiotic<br />
+
**[[3rxw]], [[3rxx]], [[2ov5]], [[5ul8]] – KpBlac Kpc-2
-
**[[3rxw]], [[3rxx]], [[2ov5]], [[5ul8]] – KpBlac Kpc<br />
+
**[[6xd5]] - KpBlac Kpc-2 (mutant)<br />
-
**[[5eec]], [[6td1]] - KpBlac Kpc-2 + boronic acid inhibitor<br />
+
-
**[[4zbe]], [[6b1y]], [[6b1x]], [[6b1w]], [[6b1j]], [[6b1h]], [[6b1f]], [[6d15]], [[6d16]], [[6d17]], [[6d18]], [[6d19]], [[6j8q]], [[6jn3]], [[6jn4]], [[6jn5]], [[6m7i]], [[6mey]], [[6mll]], [[6mnp]], [[6qw9]], [[6td0]], [[6v1j]] - KpBlac Kpc-2 + inhibitor<br />
+
-
**[[5uj3]], [[5uj4]] - KpBlac Kpc-2 + antibiotic<br />
+
-
**[[5mgi]] - KoBlac Kpc-2 + boronic acid inhibitor - ''Klebsiella oxytoca'' <br />
+
**[[6qwd]] - KpBlac Kpc-3<br />
**[[6qwd]] - KpBlac Kpc-3<br />
-
**[[6qwa]] - KpBlac Kpc-3 + inhibitor<br />
 
**[[6qwe]] - KpBlac Kpc-4<br />
**[[6qwe]] - KpBlac Kpc-4<br />
-
**[[6qwb]], [[6qwc]] - KpBlac Kpc-4 + inhibitor<br />
+
**[[6z21]], [[6z22]] - KpBlac Kpc-4 (mutant)<br />
-
**[[4eqi]] – SfBlac Sfc-1<br />
+
**[[4eqi]] – SfBlac Sfc-1
-
**[[4euz]], [[4ev4]] – SfBlac Sfc-1 (mutant) + antibiotic<br />
+
**[[4jf5]], [[4jf6]] - AbBlac Oxa-23 <br />
**[[4jf5]], [[4jf6]] - AbBlac Oxa-23 <br />
-
**[[4jf4]] - AbBlac Oxa-23 + antibiotic<br />
 
**[[4oh0]], [[4z9q]] - AbBlac Oxa-58 <br />
**[[4oh0]], [[4z9q]] - AbBlac Oxa-58 <br />
**[[5boh]] - AbBlac Oxa-58 (mutant)<br />
**[[5boh]] - AbBlac Oxa-58 (mutant)<br />
Line 443: Line 445:
**[[6ogo]] - EcBlac Ndm-9<br />
**[[6ogo]] - EcBlac Ndm-9<br />
**[[3dw0]], [[3c5a]] - EcBlac Kpc-2 <br />
**[[3dw0]], [[3c5a]] - EcBlac Kpc-2 <br />
 +
 +
* Carbapenemase binary complexes
 +
 +
**[[6p97]], [[6p98]], [[6p99]], [[6p9c]], [[6pk0]] - KpBlac Oxa-48 + antibiotic<br />
 +
**[[3rxw]], [[3rxx]], [[2ov5]], [[5ul8]] – KpBlac Kpc<br />
 +
**[[5eec]], [[6td1]] - KpBlac Kpc-2 + boronic acid inhibitor<br />
 +
**[[4zbe]], [[6b1y]], [[6b1x]], [[6b1w]], [[6b1j]], [[6b1h]], [[6b1f]], [[6d15]], [[6d16]], [[6d17]], [[6d18]], [[6d19]], [[6j8q]], [[6jn3]], [[6jn4]], [[6jn5]], [[6m7i]], [[6mey]], [[6mll]], [[6mnp]], [[6qw9]], [[6td0]], [[6v1j]] - KpBlac Kpc-2 + inhibitor<br />
 +
**[[5uj3]], [[5uj4]], [[6v7i]], [[7a61]] - KpBlac Kpc-2 + antibiotic<br />
 +
**[[6xd7]], [[6z23]], [[6z25]] - KpBlac Kpc-2 (mutant) + antibiotic<br />
 +
**[[6qwa]] - KpBlac Kpc-3 + inhibitor<br />
 +
**[[6qwb]], [[6qwc]] - KpBlac Kpc-4 + inhibitor<br />
 +
**[[6tt8]], [[6ttc]] - KpBlac NDM-1 + inhibitor<br />
 +
**[[6lip]], [[6liz]], [[6lj0]], [[6lj1]], [[6lj2]], [[6lj4]], [[6lj5]], [[6lj6]], [[6lj7]], [[6lj8]] - KpBlac NDM-1 + drug<br />
 +
**[[4euz]], [[4ev4]] – SfBlac Sfc-1 (mutant) + antibiotic<br />
 +
**[[4jf4]] - AbBlac Oxa-23 + antibiotic<br />
**[[5ll7]] - EcBlac Kpc-2 + boronic acid inhibitor<br />
**[[5ll7]] - EcBlac Kpc-2 + boronic acid inhibitor<br />
**[[6mkq]], [[6mk6]] - Blac + inhibitor – ''Vibrio cholerae''<br />
**[[6mkq]], [[6mk6]] - Blac + inhibitor – ''Vibrio cholerae''<br />
 +
**[[5mgi]] - KoBlac Kpc-2 + boronic acid inhibitor - ''Klebsiella oxytoca'' <br />
*'''Other β-lactamase'''
*'''Other β-lactamase'''
Line 496: Line 514:
**[[6whl]] – Blac – ''Legionella pneumophila''<br />
**[[6whl]] – Blac – ''Legionella pneumophila''<br />
**[[6wjm]] – Blac – ''Desulfarculus baarsii''<br />
**[[6wjm]] – Blac – ''Desulfarculus baarsii''<br />
- 
*Other β-lactamase binary complex
*Other β-lactamase binary complex
Line 518: Line 535:
**[[6cgz]] – AaBlac + lactone derivative<br />
**[[6cgz]] – AaBlac + lactone derivative<br />
**[[6pqc]] – CdBlac (mutant) + antibiotic <br />
**[[6pqc]] – CdBlac (mutant) + antibiotic <br />
 +
**[[7doo]] – BmBlac + antibiotic <br />
}}
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 08:40, 11 May 2021

3D Structures of Beta-lactamase

Updated on 11-May-2021

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/Beta-lactamase_3D_structures"
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