1edq

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[[Image:1edq.gif|left|200px]]
[[Image:1edq.gif|left|200px]]
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{{Structure
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|PDB= 1edq |SIZE=350|CAPTION= <scene name='initialview01'>1edq</scene>, resolution 1.55&Aring;
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The line below this paragraph, containing "STRUCTURE_1edq", creates the "Structure Box" on the page.
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|SITE=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14] </span>
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{{STRUCTURE_1edq| PDB=1edq | SCENE= }}
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|RELATEDENTRY=[[1ctn|1CTN]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1edq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1edq OCA], [http://www.ebi.ac.uk/pdbsum/1edq PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1edq RCSB]</span>
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'''CRYSTAL STRUCTURE OF CHITINASE A FROM S. MARCESCENS AT 1.55 ANGSTROMS'''
'''CRYSTAL STRUCTURE OF CHITINASE A FROM S. MARCESCENS AT 1.55 ANGSTROMS'''
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[[Category: Papanikolau, Y.]]
[[Category: Papanikolau, Y.]]
[[Category: Petratos, K.]]
[[Category: Petratos, K.]]
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[[Category: beta-alpha (tim) barrel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:58:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:00:32 2008''
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Revision as of 11:58, 2 May 2008

Image:1edq.gif

Template:STRUCTURE 1edq

CRYSTAL STRUCTURE OF CHITINASE A FROM S. MARCESCENS AT 1.55 ANGSTROMS


Overview

The purification scheme of chitinase A (ChiA) from S. marcescens has been extensively revised. The pure enzyme crystallizes readily under new crystallization conditions. The ChiA crystal structure has been refined to 1.55 A resolution and the crystal structure of ChiA co-crystallized with the inhibitor allosamidin has been refined to 1.9 A resolution. Allosamidin is located in the deep active-site tunnel of ChiA and interacts with three important residues: Glu315, the proton donor of the catalysis, Asp313, which adopts two conformations in the native structure but is oriented towards Glu315 in the inhibitor complex, and Tyr390, which lies opposite Glu315 in the active-site tunnel.

About this Structure

1EDQ is a Single protein structure of sequence from Serratia marcescens. Full crystallographic information is available from OCA.

Reference

De novo purification scheme and crystallization conditions yield high-resolution structures of chitinase A and its complex with the inhibitor allosamidin., Papanikolau Y, Tavlas G, Vorgias CE, Petratos K, Acta Crystallogr D Biol Crystallogr. 2003 Feb;59(Pt 2):400-3. Epub 2003, Jan 23. PMID:12554965 Page seeded by OCA on Fri May 2 14:58:12 2008

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