1ef1

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[[Image:1ef1.gif|left|200px]]
[[Image:1ef1.gif|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1ef1", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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{{STRUCTURE_1ef1| PDB=1ef1 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ef1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ef1 OCA], [http://www.ebi.ac.uk/pdbsum/1ef1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ef1 RCSB]</span>
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'''CRYSTAL STRUCTURE OF THE MOESIN FERM DOMAIN/TAIL DOMAIN COMPLEX'''
'''CRYSTAL STRUCTURE OF THE MOESIN FERM DOMAIN/TAIL DOMAIN COMPLEX'''
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[[Category: Pearson, M A.]]
[[Category: Pearson, M A.]]
[[Category: Reczek, D.]]
[[Category: Reczek, D.]]
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[[Category: crystal structure]]
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[[Category: Crystal structure]]
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[[Category: ferm domain]]
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[[Category: Ferm domain]]
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[[Category: membrane]]
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[[Category: Membrane]]
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[[Category: tail domain]]
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[[Category: Tail domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:01:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:01:19 2008''
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Revision as of 12:01, 2 May 2008

Image:1ef1.gif

Template:STRUCTURE 1ef1

CRYSTAL STRUCTURE OF THE MOESIN FERM DOMAIN/TAIL DOMAIN COMPLEX


Overview

The ezrin-radixin-moesin (ERM) protein family link actin filaments of cell surface structures to the plasma membrane, using a C-terminal F-actin binding segment and an N-terminal FERM domain, a common membrane binding module. ERM proteins are regulated by an intramolecular association of the FERM and C-terminal tail domains that masks their binding sites. The crystal structure of a dormant moesin FERM/tail complex reveals that the FERM domain has three compact lobes including an integrated PTB/PH/ EVH1 fold, with the C-terminal segment bound as an extended peptide masking a large surface of the FERM domain. This extended binding mode suggests a novel mechanism for how different signals could produce varying levels of activation. Sequence conservation suggests a similar regulation of the tumor suppressor merlin.

About this Structure

1EF1 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domain., Pearson MA, Reczek D, Bretscher A, Karplus PA, Cell. 2000 Apr 28;101(3):259-70. PMID:10847681 Page seeded by OCA on Fri May 2 15:01:02 2008

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