2lcs
From Proteopedia
(Difference between revisions)
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==Yeast Nbp2p SH3 domain in complex with a peptide from Ste20p== | ==Yeast Nbp2p SH3 domain in complex with a peptide from Ste20p== | ||
| - | <StructureSection load='2lcs' size='340' side='right' caption='[[2lcs]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | + | <StructureSection load='2lcs' size='340' side='right'caption='[[2lcs]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2lcs]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2lcs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LCS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LCS FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NBP2, YDR162C ([ | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NBP2, YDR162C ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr> |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lcs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lcs OCA], [https://pdbe.org/2lcs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lcs RCSB], [https://www.ebi.ac.uk/pdbsum/2lcs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lcs ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/NBP2_YEAST NBP2_YEAST]] Negatively regulates the high-osmolarity glycerol (HOG) pathway through its negative regulation of the HOG1 kinase activity. Mediates the binding between the PTC1 phosphatase and the PBS2 MAP/ERK kinase (MEK). With PTC1, regulates endoplasmic reticulum inheritance through the cell wall integrity (CWI) MAPK pathway by modulating the MAPK, SLT2.<ref>PMID:14573466</ref> <ref>PMID:14685261</ref> <ref>PMID:16977319</ref> [[https://www.uniprot.org/uniprot/STE20_YEAST STE20_YEAST]] MAP4K component of the MAPK pathway required for the mating pheromone response, haploid invasive growth and diploid pseudohyphal development. Links the pheromone response G-protein beta gamma subunits to downstream signaling components. Needed for mating in haploid cells, induction of a mating-specific gene FUS1, induction of mating-specific morphologies, and pheromone-induced proliferation arrest. Required for the regulation of the actin polarization and bud emergence during cell cycle in G1. Involved in the high osmolarity glycerol (HOG) response. Phosphorylates 'Thr-307' and 'Ser-302' or 'Ser-306' of STE11 and 'Ser-357' of MYO3. Phosphorylates histone H2B to form H2BS10ph during meiosis and H(2)O(2)-induced apoptosis. Its interaction with CDC42 is required for both invasive growth and the formation of pseudohyphae. Its interaction with STE4 is required for the pheromone signaling.<ref>PMID:1464311</ref> <ref>PMID:8421676</ref> <ref>PMID:7608157</ref> <ref>PMID:9003780</ref> <ref>PMID:8722766</ref> <ref>PMID:8643578</ref> <ref>PMID:9009270</ref> <ref>PMID:9388196</ref> <ref>PMID:9742399</ref> <ref>PMID:9428767</ref> <ref>PMID:10562285</ref> <ref>PMID:10837245</ref> <ref>PMID:10970855</ref> <ref>PMID:11003652</ref> <ref>PMID:11940652</ref> <ref>PMID:12686605</ref> <ref>PMID:12588977</ref> <ref>PMID:15652479</ref> <ref>PMID:15970663</ref> <ref>PMID:15743816</ref> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Baker's yeast]] | [[Category: Baker's yeast]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Non-specific serine/threonine protein kinase]] | [[Category: Non-specific serine/threonine protein kinase]] | ||
[[Category: Davidson, A R]] | [[Category: Davidson, A R]] | ||
Revision as of 10:08, 12 May 2021
Yeast Nbp2p SH3 domain in complex with a peptide from Ste20p
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