2ljc

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==Structure of the influenza AM2-BM2 chimeric channel bound to rimantadine==
==Structure of the influenza AM2-BM2 chimeric channel bound to rimantadine==
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<StructureSection load='2ljc' size='340' side='right' caption='[[2ljc]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
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<StructureSection load='2ljc' size='340' side='right'caption='[[2ljc]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2ljc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_h3n2 Influenza a virus h3n2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LJC FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2ljc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_a_virus_h3n2 Influenza a virus h3n2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LJC FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RIM:RIMANTADINE'>RIM</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RIM:RIMANTADINE'>RIM</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2rlf|2rlf]], [[2kix|2kix]], [[2ljb|2ljb]], [[2kwx|2kwx]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2rlf|2rlf]], [[2kix|2kix]], [[2ljb|2ljb]], [[2kwx|2kwx]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BM2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=41857 Influenza A virus H3N2])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BM2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=41857 Influenza A virus H3N2])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ljc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ljc OCA], [http://pdbe.org/2ljc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ljc RCSB], [http://www.ebi.ac.uk/pdbsum/2ljc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ljc ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ljc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ljc OCA], [https://pdbe.org/2ljc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ljc RCSB], [https://www.ebi.ac.uk/pdbsum/2ljc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ljc ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/Q9YP62_9INFA Q9YP62_9INFA]] Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of the endosome triggers M2 ion channel activity. The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur. Also plays a role in viral proteins secretory pathway. Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation (By similarity).[SAAS:SAAS002089_004_400258]
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[[https://www.uniprot.org/uniprot/Q9YP62_9INFA Q9YP62_9INFA]] Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of the endosome triggers M2 ion channel activity. The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur. Also plays a role in viral proteins secretory pathway. Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation (By similarity).[SAAS:SAAS002089_004_400258]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Influenza a virus h3n2]]
[[Category: Influenza a virus h3n2]]
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[[Category: Large Structures]]
[[Category: Chou, J J]]
[[Category: Chou, J J]]
[[Category: Oxenoid, K]]
[[Category: Oxenoid, K]]

Revision as of 10:11, 12 May 2021

Structure of the influenza AM2-BM2 chimeric channel bound to rimantadine

PDB ID 2ljc

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