2lr8

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==Solution NMR Structure of CASP8-associated protein 2 from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR8150A==
==Solution NMR Structure of CASP8-associated protein 2 from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR8150A==
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<StructureSection load='2lr8' size='340' side='right' caption='[[2lr8]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2lr8' size='340' side='right'caption='[[2lr8]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2lr8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LR8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LR8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2lr8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LR8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LR8 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CASP8AP2, FLASH, KIAA1315, RIP25 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CASP8AP2, FLASH, KIAA1315, RIP25 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lr8 OCA], [http://pdbe.org/2lr8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lr8 RCSB], [http://www.ebi.ac.uk/pdbsum/2lr8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2lr8 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lr8 OCA], [https://pdbe.org/2lr8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lr8 RCSB], [https://www.ebi.ac.uk/pdbsum/2lr8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lr8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/C8AP2_HUMAN C8AP2_HUMAN]] Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase.<ref>PMID:12477726</ref> <ref>PMID:15698540</ref> <ref>PMID:17003125</ref> <ref>PMID:17245429</ref>
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[[https://www.uniprot.org/uniprot/C8AP2_HUMAN C8AP2_HUMAN]] Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase.<ref>PMID:12477726</ref> <ref>PMID:15698540</ref> <ref>PMID:17003125</ref> <ref>PMID:17245429</ref>
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Acton, T B]]
[[Category: Acton, T B]]
[[Category: Eletsky, A]]
[[Category: Eletsky, A]]

Revision as of 10:16, 12 May 2021

Solution NMR Structure of CASP8-associated protein 2 from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR8150A

PDB ID 2lr8

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