1efn

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[[Image:1efn.gif|left|200px]]
[[Image:1efn.gif|left|200px]]
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{{Structure
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|PDB= 1efn |SIZE=350|CAPTION= <scene name='initialview01'>1efn</scene>, resolution 2.5&Aring;
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The line below this paragraph, containing "STRUCTURE_1efn", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=PBM:TRIMETHYL+LEAD+ION'>PBM</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= HIV-1 NEF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), HIV-1 NEF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1])
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|DOMAIN=
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{{STRUCTURE_1efn| PDB=1efn | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1efn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1efn OCA], [http://www.ebi.ac.uk/pdbsum/1efn PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1efn RCSB]</span>
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}}
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'''HIV-1 NEF PROTEIN IN COMPLEX WITH R96I MUTANT FYN SH3 DOMAIN'''
'''HIV-1 NEF PROTEIN IN COMPLEX WITH R96I MUTANT FYN SH3 DOMAIN'''
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[[Category: Kuriyan, J.]]
[[Category: Kuriyan, J.]]
[[Category: Lee, C H.]]
[[Category: Lee, C H.]]
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[[Category: aid]]
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[[Category: Aid]]
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[[Category: atp-binding]]
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[[Category: Atp-binding]]
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[[Category: complex (sh3 domain/viral enhancer)]]
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[[Category: Gtp-binding]]
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[[Category: gtp-binding]]
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[[Category: Myristylation]]
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[[Category: myristylation]]
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[[Category: Phosphorylation]]
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[[Category: phosphorylation]]
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[[Category: Ppii helix]]
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[[Category: ppii helix]]
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[[Category: Proto-oncogene]]
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[[Category: proto-oncogene]]
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[[Category: Pxxp motif]]
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[[Category: pxxp motif]]
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[[Category: Sh2 domain]]
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[[Category: sh2 domain]]
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[[Category: Sh3 domain]]
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[[Category: sh3 domain]]
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[[Category: Transferase]]
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[[Category: transferase]]
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[[Category: Tyrosine-protein kinase]]
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[[Category: tyrosine-protein kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:02:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:01:36 2008''
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Revision as of 12:02, 2 May 2008

Image:1efn.gif

Template:STRUCTURE 1efn

HIV-1 NEF PROTEIN IN COMPLEX WITH R96I MUTANT FYN SH3 DOMAIN


Overview

The crystal structure of the conserved core of HIV-1 Nef has been determined in complex with the SH3 domain of a mutant Fyn tyrosine kinase (a single amino acid substitution, Arg-96 to isoleucine), to which Nef binds tightly. The conserved PxxP sequence motif of Nef, known to be important for optimal viral replication, is part of a polyproline type II helix that engages the SH3 domain in a manner resembling closely the interaction of isolated peptides with SH3 domains. The Nef-SH3 structure also reveals how high affinity and specificity in the SH3 interaction is achieved by the presentation of the PxxP motif within the context of the folded structure of Nef.

About this Structure

1EFN is a Protein complex structure of sequences from Homo sapiens and Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain., Lee CH, Saksela K, Mirza UA, Chait BT, Kuriyan J, Cell. 1996 Jun 14;85(6):931-42. PMID:8681387 Page seeded by OCA on Fri May 2 15:02:16 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

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