1efh

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[[Image:1efh.jpg|left|200px]]
[[Image:1efh.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1efh |SIZE=350|CAPTION= <scene name='initialview01'>1efh</scene>, resolution 2.40&Aring;
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The line below this paragraph, containing "STRUCTURE_1efh", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=A3P:ADENOSINE-3&#39;-5&#39;-DIPHOSPHATE'>A3P</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Alcohol_sulfotransferase Alcohol sulfotransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.2.2 2.8.2.2] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= CDNA LIBRARY ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_1efh| PDB=1efh | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1efh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1efh OCA], [http://www.ebi.ac.uk/pdbsum/1efh PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1efh RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF THE HUMAN HYDROXYSTEROID SULFOTRANSFERASE IN THE PRESENCE OF PAP'''
'''CRYSTAL STRUCTURE OF THE HUMAN HYDROXYSTEROID SULFOTRANSFERASE IN THE PRESENCE OF PAP'''
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[[Category: Pedersen, L C.]]
[[Category: Pedersen, L C.]]
[[Category: Petrotchenko, E V.]]
[[Category: Petrotchenko, E V.]]
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[[Category: a3p]]
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[[Category: A3p]]
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[[Category: dhea]]
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[[Category: Dhea]]
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[[Category: hydroxysteroid]]
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[[Category: Hydroxysteroid]]
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[[Category: pap]]
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[[Category: Pap]]
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[[Category: sulfotransferase]]
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[[Category: Sulfotransferase]]
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[[Category: sult2a3]]
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[[Category: Sult2a3]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:02:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:01:26 2008''
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Revision as of 12:02, 2 May 2008

Image:1efh.jpg

Template:STRUCTURE 1efh

CRYSTAL STRUCTURE OF THE HUMAN HYDROXYSTEROID SULFOTRANSFERASE IN THE PRESENCE OF PAP


Overview

The crystal structure of SULT2A3 human hydroxysteroid sulfotransferase has been solved at 2.4 A resolution in the presence of 3'-phosphoadenosine 5'-phosphate (PAP). The overall structure is similar to those of SULT1 enzymes such as estrogen sulfotransferase and the PAP binding site is conserved, however, significant differences exist in the positions of loops Pro14-Ser20, Glu79-Ile82 and Tyr234-Gln244 in the substrate binding pocket. Moreover, protein interaction in the crystal structure has revealed a possible dimer-directed conformational alteration that may regulate the SULT activity.

About this Structure

1EFH is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of SULT2A3, human hydroxysteroid sulfotransferase., Pedersen LC, Petrotchenko EV, Negishi M, FEBS Lett. 2000 Jun 9;475(1):61-4. PMID:10854859 Page seeded by OCA on Fri May 2 15:02:22 2008

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