1au3

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(New page: 200px<br /> <applet load="1au3" size="450" color="white" frame="true" align="right" spinBox="true" caption="1au3, resolution 2.5&Aring;" /> '''CRYSTAL STRUCTURE OF...)
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Revision as of 13:55, 12 November 2007

Image:1au3.gif

1au3, resolution 2.5Å

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CRYSTAL STRUCTURE OF THE CYSTEINE PROTEASE HUMAN CATHEPSIN K IN COMPLEX WITH A COVALENT PYRROLIDINONE INHIBITOR

Disease

Known disease associated with this structure: Pycnodysostosis OMIM:[601105]

About this Structure

1AU3 is a Single protein structure of sequence from Homo sapiens with PCM as ligand. Active as Cathepsin K, with EC number 3.4.22.38 Full crystallographic information is available from OCA.

Reference

Conformationally constrained 1,3-diamino ketones: a series of potent inhibitors of the cysteine protease cathepsin K., Marquis RW, Yamashita DS, Ru Y, LoCastro SM, Oh HJ, Erhard KF, DesJarlais RL, Head MS, Smith WW, Zhao B, Janson CA, Abdel-Meguid SS, Tomaszek TA, Levy MA, Veber DF, J Med Chem. 1998 Sep 10;41(19):3563-7. PMID:9733481

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