6v8y
From Proteopedia
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==Structure of a Sodium Potassium ion Channel== | ==Structure of a Sodium Potassium ion Channel== | ||
| - | <StructureSection load='6v8y' size='340' side='right'caption='[[6v8y]]' scene=''> | + | <StructureSection load='6v8y' size='340' side='right'caption='[[6v8y]], [[Resolution|resolution]] 1.53Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6V8Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6V8Y FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6v8y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_14579 Atcc 14579]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6V8Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6V8Y FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6v8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6v8y OCA], [https://pdbe.org/6v8y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6v8y RCSB], [https://www.ebi.ac.uk/pdbsum/6v8y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6v8y ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> |
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">A9485_19160, B4155_3291, BACERE00184_02078, CN419_22740, CN950_06075, CN980_22870, COI98_17615, COK18_26145, CON37_12595 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1396 ATCC 14579])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6v8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6v8y OCA], [https://pdbe.org/6v8y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6v8y RCSB], [https://www.ebi.ac.uk/pdbsum/6v8y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6v8y ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The sodium potassium ion channel (NaK) is a nonselective ion channel that conducts both sodium and potassium across the cellular membrane. A new crystallographic structure of NaK reveals conformational differences in the residues that make up the selectivity filter between the four subunits that form the ion channel and the inner helix of the ion channel. The crystallographic structure also identifies a side-entry, ion-conduction pathway for Na(+) permeation that is unique to NaK. NMR studies and molecular dynamics simulations confirmed the dynamical nature of the top part of the selectivity filter and the inner helix in NaK as also observed in the crystal structure. Taken together, these results indicate that the structural plasticity of the selectivity filter combined with the dynamics of the inner helix of NaK are vital for the efficient conduction of different ions through the non-selective ion channel of NaK. | ||
| + | |||
| + | Structural plasticity of the selectivity filter in a nonselective ion channel.,Roy RN, Hendriks K, Kopec W, Abdolvand S, Weiss KL, de Groot BL, Lange A, Sun H, Coates L IUCrJ. 2021 Apr 2;8(Pt 3):421-430. doi: 10.1107/S205225252100213X. eCollection, 2021 May 1. PMID:33953928<ref>PMID:33953928</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6v8y" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Atcc 14579]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Coates L]] | + | [[Category: Coates, L]] |
| - | [[Category: Roy R]] | + | [[Category: Roy, R]] |
| - | [[Category: Weiss | + | [[Category: Weiss, K L]] |
| + | [[Category: Ion channel]] | ||
| + | [[Category: Membrane protein]] | ||
Revision as of 10:14, 19 May 2021
Structure of a Sodium Potassium ion Channel
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