2m0q
From Proteopedia
(Difference between revisions)
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==Solution NMR analysis of intact KCNE2 in detergent micelles demonstrate a straight transmembrane helix== | ==Solution NMR analysis of intact KCNE2 in detergent micelles demonstrate a straight transmembrane helix== | ||
| - | <StructureSection load='2m0q' size='340' side='right' caption='[[2m0q]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> | + | <StructureSection load='2m0q' size='340' side='right'caption='[[2m0q]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2m0q]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2m0q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M0Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M0Q FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KCNE2 ([ | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KCNE2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m0q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m0q OCA], [https://pdbe.org/2m0q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m0q RCSB], [https://www.ebi.ac.uk/pdbsum/2m0q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m0q ProSAT]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/KCNE2_HUMAN KCNE2_HUMAN]] Familial atrial fibrillation;Romano-Ward syndrome. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. |
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/KCNE2_HUMAN KCNE2_HUMAN]] Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Associated with KCNH2/HERG is proposed to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2 and/or KCNQ3 and modulate the native M-type current. May associate with KCNQ1/KVLTQ1 and elicit a voltage-independent current. May associate with HCN1 and HCN2 and increase potassium current. |
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Chen, L]] | [[Category: Chen, L]] | ||
[[Category: Lai, C]] | [[Category: Lai, C]] | ||
Revision as of 10:57, 19 May 2021
Solution NMR analysis of intact KCNE2 in detergent micelles demonstrate a straight transmembrane helix
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Categories: Human | Large Structures | Chen, L | Lai, C | Li, P | Tian, C | Wu, F | Zhang, L | Detergent micelle | Membrane protein | Transmembrane helix
