Nuclear receptors
From Proteopedia
(Difference between revisions)
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<StructureSection load='' size='340' side='right' caption='Human androgen receptor ligand-binding domain complex with modulator (PDB code [[3b5r]])' scene='54/543362/Cv/1'> | <StructureSection load='' size='340' side='right' caption='Human androgen receptor ligand-binding domain complex with modulator (PDB code [[3b5r]])' scene='54/543362/Cv/1'> | ||
| - | '''Under development!!!''' | ||
| - | Nuclear receptor structure is composed of 5 domains | + | Nuclear receptor structure is composed of 5 domains: |
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A/B: N-terminal regulatory domain contains activation function 1 (residues 101-370), activation function 5 (residues 360-485) and dimerization surface (residues 1-36 and 370-494).<br /> | A/B: N-terminal regulatory domain contains activation function 1 (residues 101-370), activation function 5 (residues 360-485) and dimerization surface (residues 1-36 and 370-494).<br /> | ||
C: DNA binding domain (DBD)<br /> | C: DNA binding domain (DBD)<br /> | ||
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See also [[Receptor]] | See also [[Receptor]] | ||
| - | '''Family members (~ according to [https://en.wikipedia.org/wiki/Nuclear_receptor]):''' | ||
=Thyroid Hormone Receptor-like= | =Thyroid Hormone Receptor-like= | ||
==Thyroid hormone receptor== | ==Thyroid hormone receptor== | ||
Revision as of 13:44, 23 May 2021
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References
- ↑ Bohl CE, Wu Z, Chen J, Mohler ML, Yang J, Hwang DJ, Mustafa S, Miller DD, Bell CE, Dalton JT. Effect of B-ring substitution pattern on binding mode of propionamide selective androgen receptor modulators. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5567-70. Epub 2008 Sep 5. PMID:18805694 doi:10.1016/j.bmcl.2008.09.002
- ↑ Li MJ, Greenblatt HM, Dym O, Albeck S, Pais A, Gunanathan C, Milstein D, Degani H, Sussman JL. Structure of estradiol metal chelate and estrogen receptor complex: The basis for designing a new class of selective estrogen receptor modulators. J Med Chem. 2011 Apr 7. PMID:21473635 doi:10.1021/jm200192y
