7emk
From Proteopedia
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==Dendrorhynchus zhejiangensis ferritin== | ==Dendrorhynchus zhejiangensis ferritin== | ||
| - | <StructureSection load='7emk' size='340' side='right'caption='[[7emk]]' scene=''> | + | <StructureSection load='7emk' size='340' side='right'caption='[[7emk]], [[Resolution|resolution]] 2.30Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EMK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EMK FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7emk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dendrorhynchus_sinensis Dendrorhynchus sinensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EMK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EMK FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7emk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7emk OCA], [https://pdbe.org/7emk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7emk RCSB], [https://www.ebi.ac.uk/pdbsum/7emk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7emk ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7emk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7emk OCA], [https://pdbe.org/7emk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7emk RCSB], [https://www.ebi.ac.uk/pdbsum/7emk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7emk ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Ferritin is an important hub of iron metabolism because it stores iron during times of iron overload and releases iron during iron deficiency. Here, we present the first crystal structure of ferritin from the marine invertebrate Dendrorhynchus zhejiangensis with a 2.3 A resolution. D. zhejiangensis ferritin (DzFer) exhibits a common cage-shaped hollow sphere with 24 subunits containing the ferroxidase centers and 3-fold and 4-fold channels. The structure of DzFer shows highly conserved catalytic residues in the ferroxidase center. The metal wire formed by ferrous ions in the 3-fold channel reveals the path that iron ions use to enter and translocate into the ferroxidase site to be oxidized and finally arrive at the nucleation site. However, the electrostatic environment of the channels and pores exhibits significant and extensive variability, suggesting that ferritins execute diverse functions in different environments. | ||
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| + | Structure determination of ferritin from Dendrorhynchus zhejiangensis.,Huan H, Jiang Q, Wu Y, Qiu X, Lu C, Su C, Zhou J, Li Y, Ming T, Su X Biochem Biophys Res Commun. 2020 Oct 15;531(2):195-202. doi:, 10.1016/j.bbrc.2020.07.069. Epub 2020 Aug 10. PMID:32792196<ref>PMID:32792196</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7emk" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Dendrorhynchus sinensis]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Huan | + | [[Category: Huan, H S]] |
| - | [[Category: Ming | + | [[Category: Ming, T H]] |
| - | [[Category: Su | + | [[Category: Su, X R]] |
| + | [[Category: Dendrorhynchus zhejiangensis]] | ||
| + | [[Category: Ferritin]] | ||
| + | [[Category: Structural protein]] | ||
Revision as of 09:27, 26 May 2021
Dendrorhynchus zhejiangensis ferritin
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