1a3y

From Proteopedia

(Difference between revisions)

Revision as of 09:41, 26 May 2021

ODORANT BINDING PROTEIN FROM NASAL MUCOSA OF PIG

Structural highlights

1a3y is a 2 chain structure with sequence from Sus scrofa. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[OBP_PIG] This protein is found in nasal epithelium and it binds a wide variety of chemical odorants.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The X-ray structure of the porcine odorant binding protein (OBPp) was determined at 2.25 A resolution. This lipocalin is a monomer and is devoid of naturally occurring bound ligand, contrary to what was observed in the case of bovine OBP [Tegoni, M., et al. (1996) Nat. Struct. Biol. 3, 863-867; Bianchet, M. A., et al. (1996) Nat. Struct. Biol. 3, 934-939]. In this latter protein, a dimer without any disulfide bridges, domain swapping was found to occur between the beta- and alpha-domains. A single Gly (121) insertion was found in OBPp when it was compared to OBPb, which may prevent domain swapping from taking place. The presence of a disulfide bridge between the OBPp beta- and alpha-domains (cysteines 63 and 155) may lock the resulting fold in a nonswapped monomeric conformation. Comparisons with other OBPs indicate that the two cysteines involved in the OBPp disulfide bridge are conserved in the sequence, suggesting that OBPp may be considered a prototypic OBP fold, and not OBPb.

The structure of the monomeric porcine odorant binding protein sheds light on the domain swapping mechanism.,Spinelli S, Ramoni R, Grolli S, Bonicel J, Cambillau C, Tegoni M Biochemistry. 1998 Jun 2;37(22):7913-8. PMID:9609684^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Spinelli S, Ramoni R, Grolli S, Bonicel J, Cambillau C, Tegoni M. The structure of the monomeric porcine odorant binding protein sheds light on the domain swapping mechanism. Biochemistry. 1998 Jun 2;37(22):7913-8. PMID:9609684 doi:10.1021/bi980179e

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1a3y"

@@ Line 3: / Line 3: @@
 <StructureSection load='1a3y' size='340' side='right'caption='[[1a3y]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1a3y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A3Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1A3Y FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1a3y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A3Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A3Y FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a3y OCA], [http://pdbe.org/1a3y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1a3y RCSB], [http://www.ebi.ac.uk/pdbsum/1a3y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1a3y ProSAT]</span></td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a3y OCA], [https://pdbe.org/1a3y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a3y RCSB], [https://www.ebi.ac.uk/pdbsum/1a3y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a3y ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/OBP_PIG OBP_PIG]] This protein is found in nasal epithelium and it binds a wide variety of chemical odorants.
+[[https://www.uniprot.org/uniprot/OBP_PIG OBP_PIG]] This protein is found in nasal epithelium and it binds a wide variety of chemical odorants.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 29: / Line 29: @@
 ==See Also==
-*[[Odorant binding protein|Odorant binding protein]]
 *[[Odorant binding protein 3D structures|Odorant binding protein 3D structures]]
 == References ==

1a3y

From Proteopedia

Revision as of 09:41, 26 May 2021

ODORANT BINDING PROTEIN FROM NASAL MUCOSA OF PIG

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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