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2mdp
From Proteopedia
(Difference between revisions)
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==The bacteriophage T7 encoded inhibitor (gp1.2) of E. coli dGTP triphosphohydrolase== | ==The bacteriophage T7 encoded inhibitor (gp1.2) of E. coli dGTP triphosphohydrolase== | ||
| - | <StructureSection load='2mdp' size='340' side='right' caption='[[2mdp]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> | + | <StructureSection load='2mdp' size='340' side='right'caption='[[2mdp]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2mdp]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2mdp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bpt7 Bpt7]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MDP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MDP FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">1.2 ([ | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">1.2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10760 BPT7])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mdp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mdp OCA], [https://pdbe.org/2mdp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mdp RCSB], [https://www.ebi.ac.uk/pdbsum/2mdp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mdp ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/GP12_BPT7 GP12_BPT7]] Plays a role in increasing the intracellular pool of dGTP. Interacts with and inhibits host dGTPase/dgt. The complex made of the host dGTPase and gene 1.2 protein creates a GTP-binding site of high affinity. Subsequent binding of GTP to the enzyme-inhibitor complex inhibits its dissociation.<ref>PMID:2155228</ref> <ref>PMID:3549718</ref> |
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Bpt7]] | [[Category: Bpt7]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: London, R E]] | [[Category: London, R E]] | ||
[[Category: Mueller, G A]] | [[Category: Mueller, G A]] | ||
[[Category: Dntpase inhibitor]] | [[Category: Dntpase inhibitor]] | ||
[[Category: Viral protein]] | [[Category: Viral protein]] | ||
Revision as of 10:08, 26 May 2021
The bacteriophage T7 encoded inhibitor (gp1.2) of E. coli dGTP triphosphohydrolase
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