Caspase

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<StructureSection load='1pyo' size='350' side='right' scene='45/458455/Cv/1' caption='CASP-2 subunit P18 (purple, yellow) and subunit P12 (green, cyan) complex with polypeptide inhibitor (salmon, blue), aspartic aldehyde and acetyl group, [[1pyo]]'>
<StructureSection load='1pyo' size='350' side='right' scene='45/458455/Cv/1' caption='CASP-2 subunit P18 (purple, yellow) and subunit P12 (green, cyan) complex with polypeptide inhibitor (salmon, blue), aspartic aldehyde and acetyl group, [[1pyo]]'>
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'''Caspase''' (CASP) are cysteine-aspartic proteases (see [[Protease]]) which function in apoptosis, necrosis and inflammation. Twelve CASP have been identified in human. CASP is synthesized as an inactive pro-CASP with a prodomain which is being cleaved off to render them active. The X-linked inhibitor of apoptosis protein (XIAP) with its baculoviral IAP repeat (BIR) domain is an inhibitor of CASP.<br />
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'''Caspase''' (CASP) are cysteine-aspartic proteases (see [[Protease]]) which function in apoptosis, necrosis and inflammation. Twelve CASP have been identified in human. CASP is synthesized as an inactive pro-CASP with a prodomain which is being cleaved off to render them active. The X-linked inhibitor of apoptosis protein (XIAP) with its baculoviral IAP repeat (BIR) domain is an inhibitor of CASP. The CASP recruitment domain (CARD) mediates signaling events that are associated with various human diseases including cancer, neuro-degenerative diseases and immune disorders<ref>PMID:30664151</ref>.<br />
* '''CASP-1''' (or '''Interleukin-1 beta converting enzyme, ICE''') cleaves precursor cytokine interleukin 1-β and interleukin 18 into mature protein. See:<br />
* '''CASP-1''' (or '''Interleukin-1 beta converting enzyme, ICE''') cleaves precursor cytokine interleukin 1-β and interleukin 18 into mature protein. See:<br />
[[Human Caspase-1]]<br />
[[Human Caspase-1]]<br />

Current revision

CASP-2 subunit P18 (purple, yellow) and subunit P12 (green, cyan) complex with polypeptide inhibitor (salmon, blue), aspartic aldehyde and acetyl group, 1pyo

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References

  1. ↑ Park HH. Caspase recruitment domains for protein interactions in cellular signaling (Review). Int J Mol Med. 2019 Mar;43(3):1119-1127. doi: 10.3892/ijmm.2019.4060. Epub 2019, Jan 11. PMID:30664151 doi:http://dx.doi.org/10.3892/ijmm.2019.4060
  2. ↑ Lagrange B, Benaoudia S, Wallet P, Magnotti F, Provost A, Michal F, Martin A, Di Lorenzo F, Py BF, Molinaro A, Henry T. Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11. Nat Commun. 2018 Jan 16;9(1):242. doi: 10.1038/s41467-017-02682-y. PMID:29339744 doi:http://dx.doi.org/10.1038/s41467-017-02682-y
  3. ↑ Schweizer A, Briand C, Grutter MG. Crystal structure of caspase-2, apical initiator of the intrinsic apoptotic pathway. J Biol Chem. 2003 Oct 24;278(43):42441-7. Epub 2003 Aug 14. PMID:12920126 doi:http://dx.doi.org/10.1074/jbc.M304895200
  4. ↑ Wilson KP, Black JA, Thomson JA, Kim EE, Griffith JP, Navia MA, Murcko MA, Chambers SP, Aldape RA, Raybuck SA, et al.. Structure and mechanism of interleukin-1 beta converting enzyme. Nature. 1994 Jul 28;370(6487):270-5. PMID:8035875 doi:http://dx.doi.org/10.1038/370270a0

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