6nto
From Proteopedia
(Difference between revisions)
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==Crystal Structure of Recombinant Human Acetylcholinesterase Inhibited by A-230== | ==Crystal Structure of Recombinant Human Acetylcholinesterase Inhibited by A-230== | ||
| - | <StructureSection load='6nto' size='340' side='right'caption='[[6nto]]' scene=''> | + | <StructureSection load='6nto' size='340' side='right'caption='[[6nto]], [[Resolution|resolution]] 2.05Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NTO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NTO FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6nto]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NTO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NTO FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6nto FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nto OCA], [https://pdbe.org/6nto PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6nto RCSB], [https://www.ebi.ac.uk/pdbsum/6nto PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6nto ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7PE:2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL'>7PE</scene>, <scene name='pdbligand=L2Y:(S)-N-[(1E)-1-(diethylamino)ethylidene]-P-methylphosphonamidic+fluoride'>L2Y</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene></td></tr> |
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[6ntg|6ntg]], [[6nth|6nth]], [[6ntk|6ntk]], [[6ntl|6ntl]], [[6ntm|6ntm]], [[6ntn|6ntn]]</div></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ACHE ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6nto FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nto OCA], [https://pdbe.org/6nto PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6nto RCSB], [https://www.ebi.ac.uk/pdbsum/6nto PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6nto ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/ACES_HUMAN ACES_HUMAN]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.<ref>PMID:2714437</ref> <ref>PMID:1748670</ref> <ref>PMID:1517212</ref> <ref>PMID:11985878</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Acetylcholinesterase]] | ||
| + | [[Category: Human]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Bester | + | [[Category: Bester, S M]] |
| - | [[Category: Guelta | + | [[Category: Guelta, M A]] |
| - | [[Category: Height | + | [[Category: Height, J J]] |
| - | [[Category: Pegan | + | [[Category: Pegan, S D]] |
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Hydrolase-hydrolase inhibitor complex]] | ||
| + | [[Category: Inhibitor]] | ||
Revision as of 14:43, 2 June 2021
Crystal Structure of Recombinant Human Acetylcholinesterase Inhibited by A-230
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