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7dp3

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==Human MCM8 N-terminal domain==
==Human MCM8 N-terminal domain==
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<StructureSection load='7dp3' size='340' side='right'caption='[[7dp3]]' scene=''>
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<StructureSection load='7dp3' size='340' side='right'caption='[[7dp3]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DP3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DP3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7dp3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DP3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DP3 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dp3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dp3 OCA], [https://pdbe.org/7dp3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dp3 RCSB], [https://www.ebi.ac.uk/pdbsum/7dp3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dp3 ProSAT]</span></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MCM8, C20orf154 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/DNA_helicase DNA helicase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.12 3.6.4.12] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dp3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dp3 OCA], [https://pdbe.org/7dp3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dp3 RCSB], [https://www.ebi.ac.uk/pdbsum/7dp3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dp3 ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
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[[https://www.uniprot.org/uniprot/MCM8_HUMAN MCM8_HUMAN]] NON RARE IN EUROPE: Primary ovarian failure. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[[https://www.uniprot.org/uniprot/MCM8_HUMAN MCM8_HUMAN]] Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR) (PubMed:23401855). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity (PubMed:26215093). Probably by regulating the localization of the MNR complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs (PubMed:23401855). The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression (PubMed:23401855). However, may play a non-essential for DNA replication: may be involved in the activation of the prereplicative complex (pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex (ORC) (PubMed:15684404). Probably by regulating HR, plays a key role during gametogenesis (By similarity). Stabilizes MCM9 protein (PubMed:23401855, PubMed:26215093).[UniProtKB:Q9CWV1]<ref>PMID:15684404</ref> <ref>PMID:23401855</ref> <ref>PMID:26215093</ref>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: DNA helicase]]
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[[Category: Human]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Li J]]
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[[Category: Li, J]]
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[[Category: Liu L]]
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[[Category: Liu, L]]
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[[Category: Liu Y]]
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[[Category: Liu, Y]]
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[[Category: Dna binding]]
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[[Category: Dna binding protein]]
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[[Category: Zinc finger]]

Revision as of 14:50, 2 June 2021

Human MCM8 N-terminal domain

PDB ID 7dp3

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