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2miq
From Proteopedia
(Difference between revisions)
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==Solution NMR Structure of PHD Type 1 Zinc Finger Domain 1 of Lysine-specific Demethylase Lid from Drosophila melanogaster, Northeast Structural Genomics Consortium (NESG) Target FR824J== | ==Solution NMR Structure of PHD Type 1 Zinc Finger Domain 1 of Lysine-specific Demethylase Lid from Drosophila melanogaster, Northeast Structural Genomics Consortium (NESG) Target FR824J== | ||
| - | <StructureSection load='2miq' size='340' side='right' caption='[[2miq]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | + | <StructureSection load='2miq' size='340' side='right'caption='[[2miq]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2miq]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2miq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drome Drome]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MIQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MIQ FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CG9088, lid ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CG9088, lid ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2miq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2miq OCA], [https://pdbe.org/2miq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2miq RCSB], [https://www.ebi.ac.uk/pdbsum/2miq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2miq ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/KDM5_DROME KDM5_DROME]] Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Specifically demethylates trimethylated H3 'Lys-4'. Required for the correct regulation of homeotic genes during development.<ref>PMID:11014813</ref> <ref>PMID:17311883</ref> <ref>PMID:17351631</ref> <ref>PMID:17351630</ref> |
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Drome]] | [[Category: Drome]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: CEBS, Chaperone-Enabled Studies of Epigenetic Regulation Enzymes]] | [[Category: CEBS, Chaperone-Enabled Studies of Epigenetic Regulation Enzymes]] | ||
[[Category: Eletsky, A]] | [[Category: Eletsky, A]] | ||
Revision as of 15:15, 2 June 2021
Solution NMR Structure of PHD Type 1 Zinc Finger Domain 1 of Lysine-specific Demethylase Lid from Drosophila melanogaster, Northeast Structural Genomics Consortium (NESG) Target FR824J
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Categories: Drome | Large Structures | CEBS, Chaperone-Enabled Studies of Epigenetic Regulation Enzymes | Eletsky, A | Everett, J K | Janjua, H | Maglaqui, M | Montelione, G T | Structural genomic | Shastry, R | Sukumaran, D K | Szyperski, T | Xiao, R | Xu, X | Ceb | Chaperone-enabled studies of epigenetic regulation enzyme | Nesg | Oxidoreductase | Psi-biology | Zinc finger
