2mow
From Proteopedia
(Difference between revisions)
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==Structure of Nrd1p CID - Trf4p NIM complex== | ==Structure of Nrd1p CID - Trf4p NIM complex== | ||
| - | <StructureSection load='2mow' size='340' side='right' caption='[[2mow]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | + | <StructureSection load='2mow' size='340' side='right'caption='[[2mow]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2mow]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2mow]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MOW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MOW FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NRD1, YNL251C, N0868 ([ | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NRD1, YNL251C, N0868 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mow FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mow OCA], [https://pdbe.org/2mow PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mow RCSB], [https://www.ebi.ac.uk/pdbsum/2mow PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mow ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/NRD1_YEAST NRD1_YEAST]] Plays a role in sequence-specific regulation of nuclear pre-mRNA abundance. [[https://www.uniprot.org/uniprot/PAP2_YEAST PAP2_YEAST]] Catalytic subunit of the TRAMP complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism limiting inappropriate expression of genetic information. Polyadenylation is required for the degradative activity of the exosome on several of its nuclear RNA substrates like cryptic transcripts generated by RNA polymerase II and III, or hypomethylated pre-tRNAi-Met. Polyadenylates RNA processing and degradation intermediates of snRNAs, snoRNAs and mRNAs that accumulate in strains lacking a functional exosome. TRF4 is also required for proper nuclear division in mitosis, DNA damage repair and sister chromatid cohesion. Involved in the regulation of histone mRNA levels. May mediate mitotic chromosome condensation.<ref>PMID:8647385</ref> <ref>PMID:8895658</ref> <ref>PMID:8710513</ref> <ref>PMID:10066793</ref> <ref>PMID:10926539</ref> <ref>PMID:12062100</ref> <ref>PMID:11861546</ref> <ref>PMID:12665575</ref> <ref>PMID:15145828</ref> <ref>PMID:15935758</ref> <ref>PMID:15935759</ref> <ref>PMID:16260630</ref> <ref>PMID:15828860</ref> <ref>PMID:16373491</ref> <ref>PMID:16431988</ref> <ref>PMID:17179095</ref> <ref>PMID:20696927</ref> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Atcc 18824]] | [[Category: Atcc 18824]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Kabzinski, T]] | [[Category: Kabzinski, T]] | ||
[[Category: Kubicek, K]] | [[Category: Kubicek, K]] | ||
Revision as of 15:18, 2 June 2021
Structure of Nrd1p CID - Trf4p NIM complex
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