2mp1
From Proteopedia
(Difference between revisions)
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==Solution structure of the human chemokine CCL19== | ==Solution structure of the human chemokine CCL19== | ||
| - | <StructureSection load='2mp1' size='340' side='right' caption='[[2mp1]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | + | <StructureSection load='2mp1' size='340' side='right'caption='[[2mp1]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2mp1]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2mp1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MP1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MP1 FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CCL19, ELC, MIP3B, SCYA19 ([ | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CCL19, ELC, MIP3B, SCYA19 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mp1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mp1 OCA], [https://pdbe.org/2mp1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mp1 RCSB], [https://www.ebi.ac.uk/pdbsum/2mp1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mp1 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/CCL19_HUMAN CCL19_HUMAN]] May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.<ref>PMID:9498785</ref> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Gabel-Eissens, S J]] | [[Category: Gabel-Eissens, S J]] | ||
[[Category: Gillitzer, M L]] | [[Category: Gillitzer, M L]] | ||
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[[Category: Ccl21]] | [[Category: Ccl21]] | ||
[[Category: Ccr7]] | [[Category: Ccr7]] | ||
| - | [[Category: Chemokine receptor]] | ||
[[Category: Chemokine]] | [[Category: Chemokine]] | ||
| + | [[Category: Chemokine receptor]] | ||
[[Category: Signaling protein]] | [[Category: Signaling protein]] | ||
Revision as of 15:18, 2 June 2021
Solution structure of the human chemokine CCL19
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