2n1w
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Solution structure of human SUMO2== | ==Solution structure of human SUMO2== | ||
| - | <StructureSection load='2n1w' size='340' side='right' caption='[[2n1w]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | + | <StructureSection load='2n1w' size='340' side='right'caption='[[2n1w]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2n1w]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2n1w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N1W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N1W FirstGlance]. <br> |
| - | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1wm3|1wm3]], [[2n1v|2n1v]], [[2n1x|2n1x]], [[2n1y|2n1y]], [[2n1z|2n1z]], [[2n20|2n20]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1wm3|1wm3]], [[2n1v|2n1v]], [[2n1x|2n1x]], [[2n1y|2n1y]], [[2n1z|2n1z]], [[2n20|2n20]]</div></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SMT3B, SMT3H2, SUMO2 ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SMT3B, SMT3H2, SUMO2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n1w OCA], [https://pdbe.org/2n1w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n1w RCSB], [https://www.ebi.ac.uk/pdbsum/2n1w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n1w ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/SUMO2_HUMAN SUMO2_HUMAN]] Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.<ref>PMID:9556629</ref> <ref>PMID:18538659</ref> <ref>PMID:18408734</ref> |
| + | |||
| + | ==See Also== | ||
| + | *[[SUMO 3D Structures|SUMO 3D Structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
| Line 15: | Line 18: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Huang, T]] | [[Category: Huang, T]] | ||
[[Category: Naik, M T]] | [[Category: Naik, M T]] | ||
Revision as of 15:25, 2 June 2021
Solution structure of human SUMO2
| |||||||||||
