Muscarinic acetylcholine receptor
From Proteopedia
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Antagonists bind to mAChR M2 at the <scene name='83/833216/Cv/4'>tyrosine lid</scene>. The antagonist interacts with protein residues <scene name='83/833216/Cv/3'>D103, Y104, S107, Y403 and N404</scene><ref>PMID:30420692</ref>. | Antagonists bind to mAChR M2 at the <scene name='83/833216/Cv/4'>tyrosine lid</scene>. The antagonist interacts with protein residues <scene name='83/833216/Cv/3'>D103, Y104, S107, Y403 and N404</scene><ref>PMID:30420692</ref>. | ||
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| + | See also: | ||
| + | * [[G protein-coupled receptor]] | ||
| + | *[[Receptor]] | ||
| + | *[[Transmembrane (cell surface) receptors]] | ||
</StructureSection> | </StructureSection> | ||
Revision as of 13:59, 3 June 2021
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3D Structures of muscarinic acetylcholine receptors
Updated on 03-June-2021
References
- ↑ Ishii M, Kurachi Y. Muscarinic acetylcholine receptors. Curr Pharm Des. 2006;12(28):3573-81. doi: 10.2174/138161206778522056. PMID:17073660 doi:http://dx.doi.org/10.2174/138161206778522056
- ↑ Ockenga W, Kuhne S, Bocksberger S, Banning A, Tikkanen R. Non-neuronal functions of the m2 muscarinic acetylcholine receptor. Genes (Basel). 2013 Apr 2;4(2):171-97. doi: 10.3390/genes4020171. PMID:24705159 doi:http://dx.doi.org/10.3390/genes4020171
- ↑ Jiang S, Li Y, Zhang C, Zhao Y, Bu G, Xu H, Zhang YW. M1 muscarinic acetylcholine receptor in Alzheimer's disease. Neurosci Bull. 2014 Apr;30(2):295-307. doi: 10.1007/s12264-013-1406-z. Epub 2014 , Mar 3. PMID:24590577 doi:http://dx.doi.org/10.1007/s12264-013-1406-z
- ↑ Eglen RM. Muscarinic receptor subtype pharmacology and physiology. Prog Med Chem. 2005;43:105-36. doi: 10.1016/S0079-6468(05)43004-0. PMID:15850824 doi:http://dx.doi.org/10.1016/S0079-6468(05)43004-0
- ↑ Suno R, Lee S, Maeda S, Yasuda S, Yamashita K, Hirata K, Horita S, Tawaramoto MS, Tsujimoto H, Murata T, Kinoshita M, Yamamoto M, Kobilka BK, Vaidehi N, Iwata S, Kobayashi T. Structural insights into the subtype-selective antagonist binding to the M2 muscarinic receptor. Nat Chem Biol. 2018 Dec;14(12):1150-1158. doi: 10.1038/s41589-018-0152-y. Epub, 2018 Nov 12. PMID:30420692 doi:http://dx.doi.org/10.1038/s41589-018-0152-y
