6sdg

From Proteopedia

(Difference between revisions)

Revision as of 15:26, 8 June 2021

Crystal structure of the DNA binding domain of M. polymorpha Auxin Response Factor 2 (MpARF2) in complex with High Affinity DNA

Structural highlights

6sdg is a 4 chain structure with sequence from Liverwort. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:	MpARF2 (Liverwort)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[A0A0K2QVG1_MARPO] Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs).[RuleBase:RU004561]

Publication Abstract from PubMed

Auxin controls numerous growth processes in land plants through a gene expression system that modulates ARF transcription factor activity(1-3). Gene duplications in families encoding auxin response components have generated tremendous complexity in most land plants, and neofunctionalization enabled various unique response outputs during development(1,3,4). However, it is unclear what fundamental biochemical principles underlie this complex response system. By studying the minimal system in Marchantia polymorpha, we derive an intuitive and simple model where a single auxin-dependent A-ARF activates gene expression. It is antagonized by an auxin-independent B-ARF that represses common target genes. The expression patterns of both ARF proteins define developmental zones where auxin response is permitted, quantitatively tuned or prevented. This fundamental design probably represents the ancestral system and formed the basis for inflated, complex systems.

Design principles of a minimal auxin response system.,Kato H, Mutte SK, Suzuki H, Crespo I, Das S, Radoeva T, Fontana M, Yoshitake Y, Hainiwa E, van den Berg W, Lindhoud S, Ishizaki K, Hohlbein J, Borst JW, Boer DR, Nishihama R, Kohchi T, Weijers D Nat Plants. 2020 May;6(5):473-482. doi: 10.1038/s41477-020-0662-y. Epub 2020 May , 15. PMID:32415296^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Kato H, Mutte SK, Suzuki H, Crespo I, Das S, Radoeva T, Fontana M, Yoshitake Y, Hainiwa E, van den Berg W, Lindhoud S, Ishizaki K, Hohlbein J, Borst JW, Boer DR, Nishihama R, Kohchi T, Weijers D. Design principles of a minimal auxin response system. Nat Plants. 2020 May;6(5):473-482. doi: 10.1038/s41477-020-0662-y. Epub 2020 May , 15. PMID:32415296 doi:http://dx.doi.org/10.1038/s41477-020-0662-y

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6sdg"

@@ Line 3: / Line 3: @@
 <StructureSection load='6sdg' size='340' side='right'caption='[[6sdg]], [[Resolution|resolution]] 2.96&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[6sdg]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Liverwort Liverwort]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SDG OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6SDG FirstGlance]. <br>
+<table><tr><td colspan='2'>[[6sdg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Liverwort Liverwort]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SDG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6SDG FirstGlance]. <br>
-</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MpARF2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3197 Liverwort])</td></tr>
+</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MpARF2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3197 Liverwort])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6sdg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sdg OCA], [http://pdbe.org/6sdg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sdg RCSB], [http://www.ebi.ac.uk/pdbsum/6sdg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sdg ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6sdg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sdg OCA], [https://pdbe.org/6sdg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6sdg RCSB], [https://www.ebi.ac.uk/pdbsum/6sdg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6sdg ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/A0A0K2QVG1_MARPO A0A0K2QVG1_MARPO]] Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs).[RuleBase:RU004561]
+[[https://www.uniprot.org/uniprot/A0A0K2QVG1_MARPO A0A0K2QVG1_MARPO]] Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs).[RuleBase:RU004561]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==

6sdg

From Proteopedia

Revision as of 15:26, 8 June 2021

Crystal structure of the DNA binding domain of M. polymorpha Auxin Response Factor 2 (MpARF2) in complex with High Affinity DNA

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

Personal tools

Navigation

Search

Toolbox