2n52

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==The solution structure of the kallikrein inhibitor SPINK6==
==The solution structure of the kallikrein inhibitor SPINK6==
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<StructureSection load='2n52' size='340' side='right' caption='[[2n52]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2n52' size='340' side='right'caption='[[2n52]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2n52]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N52 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N52 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2n52]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N52 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N52 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SPINK6, UNQ844/PRO1782 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SPINK6, UNQ844/PRO1782 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n52 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n52 OCA], [http://pdbe.org/2n52 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n52 RCSB], [http://www.ebi.ac.uk/pdbsum/2n52 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2n52 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n52 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n52 OCA], [https://pdbe.org/2n52 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n52 RCSB], [https://www.ebi.ac.uk/pdbsum/2n52 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n52 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ISK6_HUMAN ISK6_HUMAN]] Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn't inhibit KLK8.<ref>PMID:20667819</ref> <ref>PMID:21439340</ref>
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[[https://www.uniprot.org/uniprot/ISK6_HUMAN ISK6_HUMAN]] Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn't inhibit KLK8.<ref>PMID:20667819</ref> <ref>PMID:21439340</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Grotzinger, J]]
[[Category: Grotzinger, J]]
[[Category: Hydrolase inhibitor]]
[[Category: Hydrolase inhibitor]]
[[Category: Inhibitor]]
[[Category: Inhibitor]]

Revision as of 15:39, 8 June 2021

The solution structure of the kallikrein inhibitor SPINK6

PDB ID 2n52

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