2o2o

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==Solution structure of domain B from human CIN85 PROTEIN==
==Solution structure of domain B from human CIN85 PROTEIN==
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<StructureSection load='2o2o' size='340' side='right' caption='[[2o2o]], [[NMR_Ensembles_of_Models | 27 NMR models]]' scene=''>
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<StructureSection load='2o2o' size='340' side='right'caption='[[2o2o]], [[NMR_Ensembles_of_Models | 27 NMR models]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2o2o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O2O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2O2O FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2o2o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O2O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O2O FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SH3KBP1, CIN85 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SH3KBP1, CIN85 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2o2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o2o OCA], [http://pdbe.org/2o2o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2o2o RCSB], [http://www.ebi.ac.uk/pdbsum/2o2o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2o2o ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o2o OCA], [https://pdbe.org/2o2o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o2o RCSB], [https://www.ebi.ac.uk/pdbsum/2o2o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o2o ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SH3K1_HUMAN SH3K1_HUMAN]] Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration.<ref>PMID:12177062</ref> <ref>PMID:11894095</ref> <ref>PMID:11894096</ref> <ref>PMID:12771190</ref> <ref>PMID:12734385</ref> <ref>PMID:15090612</ref> <ref>PMID:16256071</ref> <ref>PMID:15707590</ref> <ref>PMID:16177060</ref> <ref>PMID:21834987</ref>
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[[https://www.uniprot.org/uniprot/SH3K1_HUMAN SH3K1_HUMAN]] Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration.<ref>PMID:12177062</ref> <ref>PMID:11894095</ref> <ref>PMID:11894096</ref> <ref>PMID:12771190</ref> <ref>PMID:12734385</ref> <ref>PMID:15090612</ref> <ref>PMID:16256071</ref> <ref>PMID:15707590</ref> <ref>PMID:16177060</ref> <ref>PMID:21834987</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Ababou, A]]
[[Category: Ababou, A]]
[[Category: Dikic, I]]
[[Category: Dikic, I]]

Revision as of 15:58, 8 June 2021

Solution structure of domain B from human CIN85 PROTEIN

PDB ID 2o2o

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