2o2t

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==The crystal structure of the 1st PDZ domain of MPDZ==
==The crystal structure of the 1st PDZ domain of MPDZ==
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<StructureSection load='2o2t' size='340' side='right' caption='[[2o2t]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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<StructureSection load='2o2t' size='340' side='right'caption='[[2o2t]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2o2t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O2T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2O2T FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2o2t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O2T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O2T FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MPDZ, MUPP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MPDZ, MUPP1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2o2t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o2t OCA], [http://pdbe.org/2o2t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2o2t RCSB], [http://www.ebi.ac.uk/pdbsum/2o2t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2o2t ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o2t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o2t OCA], [https://pdbe.org/2o2t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o2t RCSB], [https://www.ebi.ac.uk/pdbsum/2o2t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o2t ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MPDZ_HUMAN MPDZ_HUMAN]] Interacts with HTR2C and provokes its clustering at the cell surface (By similarity). Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses.<ref>PMID:11150294</ref> <ref>PMID:15312654</ref>
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[[https://www.uniprot.org/uniprot/MPDZ_HUMAN MPDZ_HUMAN]] Interacts with HTR2C and provokes its clustering at the cell surface (By similarity). Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses.<ref>PMID:11150294</ref> <ref>PMID:15312654</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Arrowsmith, C]]
[[Category: Arrowsmith, C]]
[[Category: Berridge, G]]
[[Category: Berridge, G]]

Revision as of 15:59, 8 June 2021

The crystal structure of the 1st PDZ domain of MPDZ

PDB ID 2o2t

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